Effect Of Allogeneic Hematopoietic Stem Cell Transplantation With Modified FC Conditioning Regimen On Sex Hormone Levels In Children With Severe Aplastic Anemia

Objective:To observe the effect of allogeneic hematopoietic stem cell transplantation(allo-HSCT)with a modified FC conditioning regimen(combining low-dose Cy with ATG and Flu)on postoperative sex hormone levels in children with severe aplastic anemia(Severe Aplastic Anemia,SAA).Methods:Retrospective analysis of 37 paediatric patients with SAA who had their first allo-HSCT in our department from January 2016 to October 2022.Among these patients,23 patients adopted the modified FC conditioning regimen in the observation group,and14 patients adopted the Bu-based pulp clearing conditioning regimen in the control group.Patients’ sex hormone levels were monitored beyond 6 months after allo-HSCT to see if there were differences between the two groups of SAA patients and between them and normal children.Results:Compared with the control group,FSH of the two groups of girl patients was different,and the results were statistically significant(P<0.05).There was no statistically significant difference between the observation group and normal children.Comparing the control group of girls with the normal girls,there were differences in FSH and LH between the two groups,and the results were statistically significant(P=0.003,P=0.043).The SAA patients in the observation group were further divided into two groups according to the sex-matching or mismatching of the donor and the recipient.The number of male patients was small and no comparability existed.There was no significant difference in sex hormone levels between gender-mismatched girl patients and gender-matched girl patients(all six items of sex hormones were P>0.05).Conclusion:The modified FC conditioning regimen has no significant effect on the postoperative sex hormone levels of SAA children treated with allo-HSCT.