Effect Of Pregabalin Combined With Quadrangle Block On Postoperative Rehabilitation Of Patients Undergoing Colorectal Surgery

Objective:To investigate the effect of pregabalin combined with quadratus lumborum block on postoperative rehabilitation of patients with colorectal cancer after radical resection.Methods:From January 2022 to October 2022,66 patients who underwent radical resection of colorectal cancer were randomly divided into G group(n=22),Q group(n=22),and PQ group(n=22).Patients in the three groups were treated with postoperative controlled intravenous analgesia(PCIA),patients in the PQ group and the Q group received bilateral quadratus lumborum block after anesthesia induction,patients in the PQ group received 150 mg pregabarin capsule before surgery,patients in the PQ group received 75 mg each at 8:00 PM and 30 minutes before surgery,patients in the Q group and group G received placebo at the same time.The VAS results at 2h(T1),12h(T2),24h(T3),48h(T4)after operation,the dose of sufentanil and remifentanil used during the operation,serum CRP and cortisol concentrations,vital signs,adverse reactions,postoperative ambulation time,extubation time,first drinking time,and postoperative hospital stay were compared among the three groups And the number of pressing the analgesic pump.Results:The resting VAS score and exercise VAS score of the three groups increased and then decreased at each time point.Compared with group G,VAS scores at rest and during movement were significantly decreased at each time point in P and Q groups(P < 0.05).Compared with group Q,VAS scores at rest and during movement were significantly decreased at each time point in group PQ(P < 0.05).Compared with group G,the intraoperative consumption of sufentanil and remifentanil was significantly decreased in PQ and Q groups(P < 0.05).Compared with group Q,the consumption of sufentanil and remifentanil was significantly decreased in group PQ(P < 0.05).Compared with group G,the concentrations of CRP and cortisol at 15 min after skin incision and 24 h after operation,and CRP at 48 h after operation were significantly decreased in PQ and Q groups(P < 0.05).Compared with group Q,the levels of CRP and cortisol 15 min after skin incision and 24 h after operation,and CRP 48 h after operation were significantly decreased in group PQ(P <0.05).There was no significant difference in cortisol level among the three groups 48 hours after operation(P > 0.05).Compared with group G,MAP and HR were significantly decreased 15 min after skin incision in PQ and Q groups(P < 0.05).Compared with group Q,MAP and HR were significantly decreased at 15 min after skin incision in group PQ(P <0.05).Compared with group G,the first ambulation time,exhaust time,drinking time and the number of pressing analgesic pump were significantly shortened in PQ and Q groups(P< 0.05).Compared with group Q,the first ambulation time,exhaust time,drinking time and the number of pressing analgesic pump were significantly shortened in group PQ(P < 0.05).There was no significant difference in postoperative hospital stay among the three groups(P > 0.05).Compared with G group,the number of postoperative nausea and vomiting in PQ group and Q group was reduced,and the incidence was significantly decreased(P <0.05).Conclusion:Preoperative oral pregabalin combined with ultrasound-guided bilateral quadratus lumborum block for patients after laparoscopic radical resection of colorectal cancer can obtain more effective analgesic effect,reduce the dose of opioids used during the operation,and the number of postoperative pressing the analgesic pump,thereby reducing the incidence of postoperative nausea and vomiting,and making the first ambulation time,drinking time and ambulation time earlier.It can accelerate the postoperative recovery of patients,and has fewer complications and better safety.