A Study Of The Association Between Psychotropic Drug Exposure And The Risk Of Venous Thromboembolism In People With Depressive Disorders

Objective:To evaluate the effect of psychotropic drug exposure on the risk of venous thromboembolism VTE disease in people with depressive disorders.Methods:This study was a case-control study,and 158 patients with VTE were selected from June 1,2017 to June 1,2022 in the medical record system database of the First Hospital of Shanxi Medical University.The 158 patients with depressive disorders who developed VTE were used as the case group,the depressive patients without VTE were matched to the control group according to sex and age 1:1,and the general information and psychotropic drug exposure of the two groups of patients with depressive disorders were retrospectively recorded.and the effect of psychotropic drug use on VTE was evaluated by binary logistic regression analysis.Results:1.Patients with depressive disorder who took psychotropic drugs had a 3.2-fold increased risk of VTE(crude OR: 3.188,95% CI: 1.492-6.813,P=0.003)compared with those who did not take psychotropic drugs;The risk of VTE increased approximately 1.5-fold for each additional psychotropic drug(a OR: 1.478,95% CI: 1.227-1.780,P<0.001).2.Studies failed to find an association between antipsychotics,anxiolytics and selective serotonin reuptake inhibitors / tricyclic antidepressants / serotonin 5-HT receptor blockers and VTE risk,but we found that taking serotonin norepinephrine reuptake inhibitors reduced the risk of VTE by 2.7-fold(a OR: 0.364,95% CI: 0.185-0.717,P=0.003),with a statistically significant difference.3.The risk of VTE was found to be associated with obesity,cancer,and exposure to psychotropic drugs.Conclusion:Taking multiple psychotropic drugs may increase the risk of VTE,but only taking SNRIs may reduce the risk of VTE compared with no SNRIs.