A Correlation Study Between Fibrinogen To Albumin Ratio And Prognosis In Heart Failure With Preserved Ejection Fraction

Objective:To investigate the association of fibrinogen to albumin ratio(FAR)with the composite endpoint event of rehospitalization or death in heart failure at 2 years in patients with HFpEF and the predictive value of FAR for prognosis.Methods:One hundred and eighty patients with heart failure with preserved ejection fraction who were hospitalized from January 2019 to February 2021 were selected,and clinical,laboratory,examination and follow-up data were gathered,including(1)general clinical data: age,gender,height,weight(calculated BMI),systolic blood pressure,diastolic blood pressure,history of smoking and alcohol consumption,NYHA classification,days of hospitalization and previous hypertension,diabetes,atrial fibrillation(2)laboratory test data: FIB,ALB,NT-pro BNP,Hb,SCr,TG,TC,Hb A1C;(3)cardiac ultrasound data:LVEF,LVEDD,LAD;(4)follow-up of all patients for 24 months to record the occurrence of the composite endpoint event of rehospitalization or death in heart failure.(1)According to the occurrence of the composite endpoint event of rehospitalization or death in heart failure at 24 months of follow-up,we divided the group with poor prognosis and the group with good prognosis,and compared the differences between the two groups in terms of general clinical data,laboratory and cardiac ultrasound measurement indexes.2.Patients were divided into the higher FAR group and the lower FAR group by median FAR,and the differences in the composition of the composite endpoint events of rehospitalization or death in heart failure within 2 years were compared between the two groups.3,The occurrence of the composite endpoint event of rehospitalization or death from heart failure within 2 years in patients with HFpEF was used as the dependent variable for univariate and multifactorial logistic regression analysis of poor prognosis within 2 years in patients with HFpEF.4.Independent risk factors that were significant in the multifactorial logistic regression analysis were used as independent variables,and Spearman’s correlation analysis between them and the number of days of current hospitalization was performed separately.5.The ROC curves were used to assess the efficacy of the above independent risk factor indicators in predicting the composite endpoint event of rehospitalization or death from heart failure within 2 years in patients with HFpEF.Results:1.Age,NYHA classification,days of hospitalization,FIB,FAR,NT-pro BNP and LAD levels were higher in the poor prognosis group than in the good prognosis group;ALB and Hb levels were lower in the poor prognosis group than in the good prognosis group,and the differences were statistically significant.2.The composition ratio of the composite endpoint event of heart failure rehospitalization or death within 2 years was significantly higher in HFpEF patients in the higher FAR group than in the lower FAR group.3.Multifactorial logistic regression analysis showed that age,FAR,LAD,and NT-pro BNP were independent risk factors for the composite endpoint event of rehospitalization or death from heart failure within 2 years in patients with HFpEF.4.Spearman correlation analysis showed that age,FAR,LAD,and NT-pro BNP were positively associated with the number of days of this hospitalization in HFpEF patients,respectively.5.Age,FAR,LAD,and NT-pro BNP were somewhat predictive of whether the composite endpoint event of rehospitalization for heart failure or death occurred within 2years in patients with HFpEF.Conclusion:The population of HFpEF patients with the composite endpoint event of rehospitalization or death from heart failure within 2 years was generally older,had higher levels of FAR,NYHA classification,NT-pro BNP and LAD,longer days of hospitalization,and lower levels of Hb and ALB,and age,FAR,LAD and NT-pro BNP were the composite endpoint of rehospitalization or death from heart failure within 2years in HFpEF patients Age,FAR,LAD,and NT-pro BNP were independent influencing factors for the event,and age,FAR,LAD,and NT-pro BNP were positively correlated with the number of days of this hospitalization in HFpEF patients,respectively,and age,FAR,LAD,and NT-pro BNP had a predictive value for the composite endpoint event of rehospitalization or death from heart failure within 2 years in HFpEF patients.