| ObjectiveSummarize the gender and age characteristics of patients with thyroid-associated ophthalmopathy（TAO）,analyze the differences in activity assessment of TAO patients using 99mTc-DTPA orbit SPECT/CT in different age groups and genders,compare with clinical activity score（CAS）,and analyze the involvement of extraocular muscles in TAO patients of different ages and genders.The aim is to provide more objective basis for the diagnosis and treatment of TAO with the help of 99m Tc-DTPA orbit SPECT/CT.MethodsA retrospective case study was conducted,and clinical data such as age,gender,clinical manifestations,and imaging examination of 794 patients who were first diagnosed with TAO and underwent 99mTc-DTPA orbit SPECT/CT examination at Shanxi Eye Hospital from January 2018 to December 2021 were retrospectively summarized.According to the gender of the patients,they were divided into two groups,and according to the age of the patients at the time of first diagnosis,they were divided into four groups.99mTc-DTPA orbit SPECT/CT and CAS were used to evaluate the activity of TAO,and 99mTc-DTPA orbit SPECT/CT was used to summarize the involvement of extraocular muscles in TAO patients.SPSS 26.0statistical software was used to process and analyze the data,and P<0.05 was considered statistically significant.ResultsThe mean age of the TAO patients was（45.12±14.55）years.Among these patients,313 were male（39.4%）,age（48.63±13.97）years,481 were female（60.6%）,age（42.83±14.48）years.Among these patients,39（4.9%）were in the<20 years age group,231（29.1%）in the 20-40 age group,396（49.9%）in the 40-60age group,and 128（16.1%）in the 60 age group.99m Tc-DTPA orbit SPECT/CT was used to evaluate the activity of TAO,results showed that 348（43.8%）patients were inactive phase and 446（56.2%）patients were active phase.CAS was used to evaluate the activity of TAO,results showed that 530（66.8%）patients were inactive phaseand264（33.2%）patients were active phase.Higher proportion of male patients were in active phase than female（P<0.05）.The older the age,the higher the proportion of the active phase（P<0.05）.Both methods had differences in different gender or age groups（P<0.05）.There was agreement between the two methods in the 20-40 and40-60 age groups（P<0.05）.Extraocular muscles were thickened in 469 patients（59.1%）,with 377 patients（80.4%）experiencing binocular involvement and 92（19.6%）patients experiencing monocular involvement.233 male patients（74.4%）experienced extraocular muscles thickening and 236 female patients（49.1%）experienced extraocular muscles thickening.Extrocular muscle involvement is more common in male patients than in female patients（P<0.05）.The frequency of involvement,from high to low,is inferior rectus muscle 585（33.1%）,superior rectus muscle 520（29.4%）,medial rectus muscle 490（27.7%）,and lateral rectus muscle171（9.7%）.Conclusion1.Gender and age characteristics of TAO:The prevalence of TAO in women is generally higher than that in men,with a male-to-female ratio of 2:3.However,in elderly populations,the prevalence rate is higher in men than in women,and the highest incidence age group is between 40-60 years old.2.99mTc-DTPA orbit SPECT/CT evaluates the activity of TAO,and male patients in the active phase are more common than female patients,with more patients in the active phase as they get older.99mTc-DTPA orbit SPECT/CT and CAS scores are consistent but also have differences,and 99mTc-DTPA orbit SPECT/CT shows a stronger ability to assess disease activity than CAS scores.3.Extrocular muscle involvement in TAO patients:Binocular involvement is more common than monocular involvement,and extrocular muscle involvement increases with age.Extrocular muscle involvement is more common in male patients than in female patients.The frequency of involvement,from high to low,is inferior rectus muscle,superior rectus muscle,medial rectus muscle,and lateral rectus muscle. |
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