Analysis Of Characteristics And Relationships Between Event Related Potentials And Cognitive Function Characteristics In First-degree Relatives Of Schizophrenia

Objective:This study investigated the characteristics and relationships between event-related potentials and cognitive function in first-degree relatives with schizophrenia.Methods:The children,siblings or parents of 46 patients in the schizophrenia group during treatment in our hospital from June 2019 to December 2020 were used as the first-degree relatives group,54 schizophrenia inpatients who met the inclusion criteria were used as the schizophrenia group,and 56 healthy employees or trainees in our hospital during the same period were used as the normal control group,and the comparison of the three groups in terms of gender and age group distribution was not statistically significant(P>0.05).All subjects were tested for event-related potential(ERP)P300,Brief Visual Memory test(BVMT-R),Hopkins vocabulary learning test(HVLT-R),Continuous Operation Test(CPT-IP).Results:1.The N1 and P2 latencies were not statistically significant in the schizophrenic,first-degree relative and normal control groups(P>0.05).The schizophrenia group had a longer latency for N2 and P3 compared to the first-degree relative group and the normal control group,with statistically significant differences(P<0.05).Compared to the control group,the P3 amplitude was lower in both the schizophrenic group and the first-degree relative group,and the difference was statistically significant(P<0.05),but there was no statistically significant difference between the schizophrenic group and the first-degree relative group(P>0.05).2.The HVLT-R(total score)was significantly lower in the schizophrenic and first-degree relative groups than in the normal control group,with statistically significant differences(P<0.05),while the differences between the schizophrenic and first-degree relative groups were not statistically significant(P>0.05).T1 was significantly lower in the schizophrenic group than in the first-degree relative group,with statistically significant differences(P<0.05),HVLT-R,T2 and T3 were significantly was lower than that of the normal control group,and HVLT-R,T1,T2 and T3 in the first-degree relative group were significantly lower than that of the normal control group,with statistically significant differences(P<0.05).3.BVMT-R(mean)was significantly lower in the schizophrenic group than in the first-degree relative group and the normal control group,and the difference was statistically significant(P<0.05),while the difference between the first-degree relative group and the normal control group was not statistically significant(P>0.05).Compared to the first-degree relative group,BVMT-R,T2 and T3 were significantly lower in the schizophrenic group,and compared to the normal control group,BVMT-R,T1,T2 and T3 were significantly lower in the schizophrenic group,and the differences were all statistically significant(P<0.05).T1,T2 and T3 were significantly lower in the first-degree relative group than in the normal control group,and the differences were statistically significant(P<0.05).4.The CPT-IP,2D,3D and 4D of patients in the schizophrenia group were statistically significant(P<0.05)compared with the first-degree relative group and the normal control group,and 2D of the first-degree relative group was significantly lower than that of the normal control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the first-degree relatives CPT-IP,3D,4D and the normal control group(P>0.05).5.The latency of event related potentials N2 and P3 was negatively correlated with HVLT-V,BVMT-V,and CPT-IP,with a statistically significant difference compared to the latter two(P<0.05).P3 amplitude was positively correlated with HVLT-V,BVMT-V,and CPT-IP,with statistically significant differences(P<0,05).Conclusion:This study shows that first-degree relatives with schizophrenia have cognitive deficits similar in part to those of the patients.The P300 results suggest that the patients have deficits in information processing speed,attentional function,and the results of the cognitive test instruments suggest that the patients have extensive cognitive impairments including memory,learning,and attention.First-degree relatives were partially consistent with the presence of cognitive deficits in patients with schizophrenia,and it is possible that their level of cognitive deficits was intermediate between that of the healthy population and schizophrenia.