| Objective: The morbidity and mortality of acute attack of bronchial asthma are in the forefront of respiratory diseases.The disease is characterized by repeated attacks and rapid changes,which brings a very serious economic burden to families and society.The purpose of this study is to observe the TCM symptoms,clinical efficacy,hospitalization days,asthma control questionnaire(ACQ-6),FEV1%pred,EOS,CRP and safety of autohemotherapy combined with Xiao Qing Long decoction in the treatment of patients with cold wheezing syndrome in acute attack of bronchial asthma.We hope to find a safe,effective and less side effects treatment for patients with cold wheeze during acute attack of bronchial asthma,which is the focus of this clinical study.Methods: From December 2021 to December 2022,59 patients with cold wheezy syndrome in the acute attack of bronchial asthma who were hospitalized in the Department of Pulmonary Diseases,Jiangxi university of traditional Chinese medicine hospital and met the inclusion criteria of this study were selected,including 29 cases in the treatment group and 30 cases in the control group.The baseline data,clinical symptoms,signs,medical history,TCM symptom score,Asthma control questionnaire(ACQ-6),FEV1%pred,EOS,CRP,liver and kidney function,blood routine,stool routine,urine routine and electrocardiogram were collected and recorded.The control group was treated with conventional western medicine,and the treatment group was treated with autohemotherapy combined with Xiao Qing Long decoction on the basis of conventional western medicine.7 days as a course of treatment,2 cycles of treatment,if less than 2 cycles based on the time of discharge.After discharge,the data of the patients were counted again,and the changes of TCM symptom score,clinical efficacy,length of hospital stay,asthma control questionnaire(ACQ-6),FEV1%pred,EOS,CRP and other indicators before and after treatment were recorded,SPSS26.0 software was used to analyze all data.Results:1.A total of 60 patients were enrolled in this study.According to the principle of randomized control,the enrolled patients were divided into 2 groups,and 1 case was excluded from the treatment group.There was no significant difference in the basic data(gender,age,TCM symptom score,ACQ-6 score,FEV1%pred,EOS,CRP)between the two groups before treatment(P>0.05),and the data of the two groups were comparable.2.Total TCM symptom score and clinical efficacy: the total TCM symptom score of the two groups decreased to different degrees compared with that before treatment.Comparison between groups: After treatment,the data of the treatment group and the control group showed that P<0.05,the data were significantly different and statistically significant,indicating that the improvement of the total symptom score of the treatment group was better than that of the control group.Comparison between groups: after treatment,the data of the treatment group and the control group showed that P<0.05,there was a significant difference in the data,which was statistically significant,indicating that the improvement of the total symptom score of the treatment group was better than that of the control group.The clinical efficacy of the two groups showed that the total effective rate of the treatment group was 72.4% and the total effective rate was 96.6%.The total effective rate of the control group was 43.3%,and the total effective rate was 86.7%.The total effective rate of the two groups was not statistically significant(P>0.05),but the total effective rate of the two groups was statistically significant(P<0.05),indicating that for the patients with cold croup in the acute stage of asthma,The total significant efficiency of autoblood therapy combined with Xiaoqinglong decoction is more obvious than that of conventional Western medicine.3.Length of hospital stay: By comparing and analyzing the length of hospital stay of the two groups of patients,it was found that there was a significant statistical difference(P<0.05),indicating that autohemotherapy combined with Xiao Qing Long decoction can shorten the length of hospital stay of patients compared with conventional western medicine treatment.4.Lung function FEV1%pred: the treatment group and the control group after treatment FEV1%pred had different degrees of increase,the data of the two groups compared with before treatment had significant statistical differences(P<0.05),indicating that the two groups of treatment programs can improve lung function;The comparison of lung function between the two groups after treatment showed that the data had significant statistical difference(P<0.05),indicating that autohemotherapy combined with Xiao Qing Long decoction was superior to conventional western medicine in improving lung function.5.Serum EOS count: the treatment group and control group after treatment EOS count all have varying degrees of decline,compared two groups of data before the treatment were statistically significant differences(P<0.05),two groups of patients after treatment serum EOS counts,the difference was statistically significant(P<0.05),the treatment group than the control group of serum EOS improvement is more obvious.6.Serum CRP: CRP in the treatment group and the control group decreased to different degrees after treatment,and the data in the two groups were significantly different from those before treatment(P<0.05).There was no statistically significant difference in serum CRP between the two groups after treatment(P>0.05),indicating that the treatment group did not significantly improve serum CRP compared with the control group.7.During the whole study,there were no adverse reactions and drug allergic reactions in the two groups,and the protocol was safe.Conclusion: Autohemotherapy combined with Xiao Qing Long decoction can improve the clinical symptoms of cold wheezing syndrome in acute attack of bronchial asthma,shorten the length of hospital stay,reduce airway inflammatory reaction,improve lung function,improve the quality of life of patients,and has good safety,which is worthy of clinical promotion. |
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