| Objective:To observe the clinical efficacy of interventional therapy of wet age-related macular degeneration(w AMD)with Chinese medicinal therapy after anti-VEGF,and evaluate its efficacy and safety.Methods:A total of 72 patients(72 eyes)with w AMD who met the diagnostic criteria admitted to the Ophthalmology Department of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from June2021 to December 2022 were randomly divided into the treatment group(36eyes)and the control group(36 eyes).The therapeutic group was given Intravitreal injection of anti-VEGF drugs(conbercept was used)and then given corresponding Chinese medicine prescriptions according to TCM syndrome differentiation,once a month,and took TCM for 15 days after each injection;while the control group was given intravitreal injection of anti-VEGF drug(conbercept was used),once a month,;and the therapy period of both groups was 3 months.At the time node follow-up review 1,2 and3 months after therapy,the therapeutic effect was assessed by comparing the best corrected visual acuity,the thickness of macular fovea retina and the changes in the leakage area of choroidal neovascularization between the two groups.Results:1.In terms of BCVA,the overall response rate increased by BCVA in The therapeutic group was 75%,and that in the control group was 62.04%,P< 0.05,which was statistically significant.The mean baseline BCVA(log MAR)of the therapeutic group was increased from 0.72±0.28 to0.39±0.12,and that of the control group was increased from 0.74±0.31 to 0.50±0.18.P < 0.05 was compared between the two groups after therapy.P values in the therapeutic group were all < 0.05 before therapy and 1,2 and 3 months after therapy,1 month after therapy and 2 and 3 months after therapy,and the difference was statistically significant.P values of the control group before therapy and 1,2 and 3 months after therapy,and 1 month after therapy and 3 months after therapy were all < 0.05,and the difference was statistically significant.The P values of 2 months after therapy were all > 0.05 compared with 1 and 3 months after therapy,and the difference was not statistically significant.2.From the perspective of CMT,comparing the overall response rate of CMT after therapy between the two groups,the overall response rate of the therapeutic group was 75%,and that of the control group was 61.11%,P<0.05,which was statistically significant.The mean baseline measurement of CMT(μm)in the therapeutic group was reduced from 375.87±13.12 to246.71±37.68,and the mean baseline measurement of CMT(μm)in the control group was reduced from 375.35±12.73 to 280.53±42.63,P < 0.05 after therapy,the difference was statistically significant.The P values of the therapeutic group were all < 0.05 before therapy and 1,2 and 3months after therapy,1 month after therapy and 2 and 3 months after therapy respectively,and there was statistical significance.P values of the control group were all < 0.05 before therapy and 1,2,3 months after therapy,and 1 month after therapy and 3 months after therapy,with statistical significance.After therapy,P values of 2 months,1 month and 3 months were all > 0.05,and the difference was not statistically significant.3.The the overall response rate of the therapeutic group was 66.67%,and that of the control group was 53.7%,P < 0.05,indicating statistical significance.4.Safety evaluation: 1 case of transient intraocular hypertension occurred in the therapeutic group;In the control group,there were 2 cases of transient ocular hypertension and 1 case of Mild subbulbar conjunctival hemorrhage.Conclusion: The efficacy of anti-VEGF intervention in the therapy of w AMD is worthy of recognition,which can reduce macular edema and exudation,reduce fundus blood vessel leakage and bleeding,and obtain higher visual benefit.Compared with pure anti-VEGF therapy,integrated Chinese and western medicine therapy is more prominent,stable and lasting,and has higher clinical application value.Long-lasting,has a high clinical application value. |
PDF Full Text Request