| Objective:Analyze the clinical characteristics of acute anterior uveitis associated with human leukocyte antigen B27(HLA-B27)and whether the activity of anterior uveitis is related to that of ankylosing spondylitis AS.Improve the cognitive level of HLA-B27 related spondylitis with previous uveitis as the main manifestation.Methods:This study is a retrospective study,selecting 27 HLA-B27 positive non infectious AAU patients,27 eyes as the case group,and 26 HLA-B27 negative non infectious AAU patients who matched the age and gender of the case group as the control group.Improve the examination of corrected vision,intraocular pressure,slit lamp microscope,non dilated direct fundoscopic examination,blood routine examination,erythrocyte sedimentation rate,C-reactive protein,blood calcium,etc.Based on the clinical manifestations of joint disease,imaging examination of the sacroiliac joint,and laboratory examination,it is further determined whether the diagnosis of AS is confirmed by a rheumatologist.Evaluate according to Hoekzema’s clinical modified scoring standard for acute anterior uveitis activity.Assess the patient’s AS activity and limb function based on the Bath ankylosing spondylitis disease activity index and Bath ankylosing spondylitis functional index.Use t-test to compare the age,corrected visual acuity,intraocular pressure,blood routine,erythrocyte sedimentation rate,C-reactive protein,blood calcium,and other measurement data between the case group and the control group.Use chi square test to analyze counting data such as slit lamp microscopy,non dilated direct fundus microscopy,and gender.The relationship between HLA-B27 positivity and other factors was analyzed using binary logistic regression analysis.Furthermore,Pearson or Spearman correlation analysis was used to determine the correlation between AAU activity and AS activity,and P<0.05 was found to be statistically significant.Results:In this study,the positive rate of patients with an AAU course of more than 1 year was significantly higher in the case group compared to the control group(P<0.05).All 27 patients in the case group were diagnosed with AS,but the correlation between AS disease activity BASDAI score,BASFI score,and AAU activity EIU score was not statistically significant(P>0.05).The median differences in c-reactive protein and NLR between the case group and the control group were statistically significant(P<0.05).The positive relationship between C-reactive protein,NLR,and HLA-B27 was statistically significant(P<0.05),with OR values of 1.147 and 2.163,respectively.The ROC analysis showed that the effectiveness of C-reactive protein and NLR in predicting HLA-B27 positive AAU was 0.707 and 0.744,respectively,both exceeding 0.7.In the case group,the correlation coefficient between BASFI score and blood calcium was-0.469,and the correlation was not statistically significant(P>0.05).The BASDAI score is negatively correlated with blood calcium,with a correlation coefficient of-0.634,which is statistically significant(P<0.05).There is a certain degree of positive correlation between NLR and kp level in the control group,with a correlation coefficient of 0.402,and the correlation is statistically significant(P>0.05).The correlation between NLR and other indicators is not statistically significant(P>0.05).Conclusion:1.There is no exact correlation between AS disease activity and AAU activity.2.The diagnostic rate of acute non infectious anterior uveitis with HLA-B27 positive AS is relatively high.3.There is a negative correlation between blood calcium level and BASDAI score,and there is a correlation between blood calcium and AS activity4.Elevated NLR and C-reactive protein values have a certain predictive effect on whether non sensitive AAU is accompanied by HLA-B27 positivity.5.NLR and PLR cannot be used as indicators to determine the activity of non infectious AAU diseases. |
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