Correlation Between Serum Ferritin Concentration And Preeclampsia

Objective:Serum ferritin is a stable glycoprotein,which is one of the main forms of iron storage in the human body,and is the most effective indicator for the evaluation of iron status.In this study,the serum ferritin concentration of pregnant women was detected to understand the iron status in pregnant women,and the correlation between iron and preeclampsia was analyzed,so as to provide more possibilities for the pathogenesis,prevention and treatment of preeclampsia.Methods:Pregnant women who received regular birth check-up in the Affiliated Hospital of Inner Mongolia Medical University from January 2021 to December 2022 were selected.General data of the survey subjects were collected in the form of questionnaire survey.Serum ferritin concentrations were measured in the first,second and third trimesters respectively,and they were divided into case group and control group according to the occurrence of preeclampsia before delivery.The case group was divided into preeclampsia group and severe preeclampsia group.Gestational diabetes mellitus(GDM)was used as a stratification factor,and subjects were divided into GDM+ preeclampsia group,that is,both GDM and preeclampsia.Simple preeclampsia group,that is,only preeclampsia;GDM group,that is,only GDM;Normal group,that is,healthy pregnant women without any complications.Statistical methods: t test was used to compare the means between two groups,analysis of variance was used to compare the means between multiple groups,and LSD method was used to compare the means after the analysis of variance was statistically significant.The adoption rate of counting data was statistically described,and chi-square test was used for statistical inference.The difference of serum ferritin level among all groups was analyzed,the influence of the severity of preeclampsia on serum ferritin level was analyzed,the influence of gestational diabetes on preeclampsia and ferritin concentration was analyzed,and the predictive significance of serum ferritin level on the occurrence and development of preeclampsia and the severity of the disease was discussed.Results:(1)In this study,54 patients were selected from the case group and 85 from the control group.In the case group,there were 14 patients with moderate to severe preeclampsia and 40 patients with preeclampsia.After stratified analysis,there were 11 patients in the preeclampsia+GDM group,43 in the simple preeclampsia group,34 in the GDM group,and 51 in the normal group.(2)Comparison of general data showed that the week of delivery and pregnancy in the case group was significantly smaller than that in the control group,and the systolic and diastolic blood pressure in the case group was significantly higher than that in the control group,with statistical significance(P<0.05).There were 6 patients in the case group and 1patient in the control group with a family history of hypertension.The difference was statistically significant(P<0.05).There were no statistically significant differences between the two groups in age,BMI in the third trimester of pregnancy,first-time birth,and smoking history(P>0.05).(3)The level of ferritin in early,middle and late pregnancy cases was significantly higher than that in control group,and the level of ferritin in early and late pregnancy severe preeclampsia group was significantly higher than that in preeclampsia group,with statistical significance(P<0.05).(4)The level of ferritin in early and late pregnancy simple preeclampsia group was significantly higher than that in GDM group and normal group.The difference was statistically significant(P<0.05).The ferritin level of simple preeclampsia group and preeclampsia +GDM group in the second trimester was significantly higher than that of GDM group and normal group,and the difference was statistically significant(P<0.05).There were no significant differences in ferritin levels between simple preeclampsia group and preeclampsia +GDM group in the first,second and third trimesters of pregnancy(P>0.05).(5)Predictive value of serum ferritin concentration for preeclampsia: area under ROC curve was 0.71 in the first trimester,0.78 in the second trimester,and 0.67 in the third trimester.Serum ferritin concentration in the second trimester was the most valuable for predicting preeclampsia.Conclusion:The serum ferritin concentration in the early,middle and late trimester groups was significantly higher than that in the control group,and the level of ferritin in the early and late trimester severe preeclampsia group was significantly higher than that in the preeclampsia group,indicating that there was a significant correlation between serum ferritin and preeclampsia,and it increased with the progression of the disease.At the same time,gestational diabetes mellitus had no significant effect on serum ferritin concentration.This study believes that iron is involved in the occurrence and development of preeclampsia,and monitoring serum ferritin concentration in the second trimester can be used as a method to predict preeclampsia.When the concentration of ferritin in the second trimester is greater than49.11μg/L,vigilance should be raised,which can warn the pregnant woman of the possibility of preeclampsia or the pregnant woman with preeclampsia may be further aggravated.Clinical can achieve early detection,early prevention and early treatment,timely avoid the occurrence of adverse pregnancy outcomes.Future studies can explore the pathogenesis of preeclampsia in the direction of iron death,and find more potential therapeutic approaches,so as to provide more possibilities for the prevention and treatment of preeclampsia.