Clinical Observation Of Tongluo Jingming Decoction Combined With Calcium Dobesilate Capsule In Treating Non-proliferative Diabetic Retinopathy With Deficiency Of Liver And Kidney,the Loss Nourishment Of Eye Collaterals Syndrome

Objective In this paper,we analyzed and evaluated the efficacy and safety of Tongluo Jingming decoction combined with calcium dobesilate capsule for the treatment of Non-proliferative Diabetic Retinopathy with deficiency liver and kidney together with the syndrome of eye collaterals deactivation.Methods In this study,Non-proliferative Diabetic Retinopathy subjects（74 patients）who visited the Department of traditional Chinese medicine of the Inner Mongolia Autonomous Region people’s Hospital from December 2021 to September 2022 and met the inclusion and exclusion criteria were selected meanwhile the subjects were divided into observation and control groups by random number table method（37patients each group）.The control group was given basal hypoglycemic therapy plus oral calcium dobesilate capsules.At the same time,the observation group was given a course of 3 months,based on the control group in combination with Tongluo Jingming decoction.During the intervention period,the changes in TCM syndrome scores,visual acuity levels,color photography of the fundus,fasting plasma glucose,glycated hemoglobin,fasting insulin,insulin resistance index,low-density lipoprotein,serum cystatin,homocysteine,interleukin 6 and other indexes were recorded in the two groups of subjects.TCM syndrome efficacy,visual acuity efficacy,as well as fundus efficacy were evaluated,statistical methods were applied to compare and analyze the differences within and between groups.Results 1.Comparison of TCM syndrome efficacy:the clinical efficacy rate of research group（88.24%）was greater than control subject（45.71%）,which was a significant difference（P<0.05）between the two sets.2.Eyesight and eyeground lesion efficacy comparison:eyesight:the clinical efficiency of the observes was83.82%,which was greater than the clinical effective rate of the control group of64.29%（P<0.05）;eyeground lesion:the overall response rate of the observation group was 85.29%,which was greater than the control group by 62.86%（P<0.05）.3.Comparison of glucose metabolism:the levels of FPG and HbA_1c in the observation group after treatment were all decreased compared with before（P<0.05）;FPG in the control group decreased more than before（P<0.05）,HbA_1c did not change notably,there was no significant difference of the treatment than before（P>0.05）;Among the groups,FPG in the observation group decreased obviously compared with that in the control group（P<0.05）;HbA_1c was not statistically different between the two groups（P>0.05）.4.Comparison of insulin levels:after treatment,FINS and HOMA-IR in the two groups decreased compared with than before,and the differences were obviously significant（P<0.05）,between the groups,FINS and HOMA-IR in the observation group improved significantly compared with the control subject（P<0.05）.5.LDL-C,Cys-C,HCY,IL-6 comparison:after treatment,LDL-C,HCY,IL-6in the two groups decreased compared with before（P<0.05）;Cys-C test group improved from before（P<0.05）,no significant change was observed in the control group（P>0.05）;the HCY and IL-6 observation group was significantly superior to the control group with statistical significance（P<0.05）between groups,while LDL-C and Cys-C had no statistical difference（P>0.05）.Conclusion 1.In the aspect of improving the TCM syndrome,visual acuity,fundus lesions,blood glucose,insulin levels,lipid profile,serum cystatin,homocysteine,interleukin 6 in patients with deficiency of liver and kidney,the loss nourishment of eye collaterals syndrome type NPDR,calcium dobesilate capsules combined with Tongluo Jingming decoction is superior to that of calcium dobesilate capsules alone;2.In delaying and controlling the progression of NPDR to PDR,Tongluo Jingming decoction combined with calcium dobesilate capsules was more effective than that of calcium dobesilate capsules alone.