| Objective: To clarify the incidence of HS in high-risk groups of cardiovascular diseases in Inner Mongolia,analyze its influencing factors,and provide scientific basis for the prevention of hemorrhagic stroke(HS)in Inner Mongolia.Methods: This study is a prospective cohort study.The multistage stratified cluster sampling method is used to establish the cohort study population.The project starts and end time is from December1,2015 to December 31,2021.During the baseline survey,the demographic information,lifestyle,disease history,blood pressure and blood lipid levels of the participants were collected through questionnaires,physical examinations and laboratory tests.Outcome was defined as first occurrence of HS or death due to first occurrence of HS.The participants were followed up once a year to record the occurrence of outcomes.The Kaplan-Meier method was used to draw the cumulative incidence curve,and the log-rank test was performed on the survival curves with different characteristics.Univariate and multivariate Cox regression analysis were used to analyze the association of gender,age,ethnicity and other factors with the incidence of hemorrhagic stroke.Results:(1)30,443 participants were finally included in the study,with an average age of 56.18±9.07 years;13,105 males(43.0%),17,338 females(57.0%);27,991 Han(91.9%),and 2,452 Mongolian(8.1%).(2)During the follow-up period,a total of 232 outcome events were collected,and the total person-year incidence rate was 237.7/100,000 person-years.The person-year incidence rate of HS in males(315.8/100,000 person-years)was higher than that in females(180.0/100,000person-years)(χ2=17.168,P<0.001);with the increase of age,the annual incidence rate of HS also increased(trend χ2=24.331,P<0.001);with the improvement of education level,the annual incidence rate of HS decreased(trend χ2=20.130,P<0.001);the annual incidence of HS in hypertensive patients(355.1/100,000 person-years)was higher than that of non-hypertensive patients(118.0/100,000 person-years)(χ2=63.163,P<0.001).(3)Multivariate Cox regression analysis showed that the risk of HS in females was significantly lower than that in males [hazard ratio(HR): 0.456,95%CI: 0.346-0.600];the risk of HS in the age of 45～ group,55～ group and 65～75 group were 3.345 times(95%CI: 1.444-7.750),3.974 times(95%CI: 1.729-9.131)and 4.633 times(95%CI:1.729-9.131)compared to the 35～ group;the risk of HS in Mongolian residents was1.679 times that of Han residents(95%CI: 1.100-2.560);the risk of HS in the secondary school and technical secondary school group(HR: 0.733,95%CI: 0.552-0.973)and the junior college,bachelor degree or above group(HR: 0.522,95%CI: 0.288-0.947)was significantly lower than that of elementary school and below group;compared with the high-density lipoprotein(HDL-C)<1.07 mmol/L group,the HDL-C≥1.60 mmol/L group had a higher risk of HS(HR: 1.515,95%CI: 1.054-2.176);the risk of HS in the group with dairy product consumption frequency ≥ 4 days per week was significantly lower than that in the group < 3 days per month(HR: 0.441,95%CI: 0.259-0.753);the risk of HS in the group with the frequency of eating aquatic products ≥ 1 day per week was significantly lower than that in the group < 3 days per month(HR: 0.622,95%CI:0.415-0.931).Conclusion: In Inner Mongolia,factors such as gender,age,ethnicity,education level,hypertension,high-density lipoprotein cholesterol,and frequency of consumption of dairy and aquatic products were associated with the risk of HS. |
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