Clinical Application Of Antibiotic-loaded Calcium Sulphate To Treat Early Periprosthetic Joint Infection After Initial Hip Arthroplasty

Objective:Periprosthetic infection(PJI)is the most serious complication after artificial joint replacement and one of the most important factors causing joint revision.However,at present,the most commonly used method in the treatment of PJI is secondary revision surgery.However,this surgical method is difficult to operate,long treatment time,high operation cost,easy to occur bone loss during the operation,and the long time interval between the two operations is easy to cause peripheral tissue contracture,and then affect the postoperative joint function recovery of patients.The purpose of this study was to explore the therapeutic effect of some cases of early postoperative PJI with simpler debridement and implantation of antibiotic-loaded Calcium Sulphate during the operation.Methods:Select 27 patients with periprosthetic infection for the first time after hip replacement treated in the First Affiliated Hospital of Gannan Medical University from January 2015 to January 2021,the patients were treated by debridement(replacement of acetabular liner)and implanted antibiotic-loaded Calcium,and the relevant data were observed and recorded.To evaluate the level of white blood cell(WBC),hip joint function(Harris score),pain degree score(VAS),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),globulin(GLB),albumin/globulin(AGR)of patients before and2 weeks afteroperation.Results:27 patients had good wound healing,good prosthesis position and no recurrence;The levels of CRP,ESR and GLB in patients 2 weeks after operation were lower than those before operation,and the level of AGR was higher than that before operation(P<0.01);Harris score of hip joint was higher than that before operation(P<0.01),and VAS score was lower than that beforeoperation(P<0.01);Conclusion:It is suggested that debridement retained prosthesis with antibiotic-loaded Calcium Sulphate is effective in the treatment of early periprosthetic infection after initial hip Arthroplasty,with a low recurrence rate of infection and satisfactory functional recovery of patients.It is a technology worthy ofclinical promotion.