To Study The Efficacy Of Photodynamic Therapy Combined With Acne Therapeutic Device In The Treatment Of Moderate To Severe Acne

Objective:To compare the clinical efficacy of photodynamic therapy combined with acne therapeutic apparatus,photodynamic therapy alone,and acne therapeutic apparatus alone in the treatment of moderate to severe acne,and preliminarily analyze the clinical value and significance of photodynamic therapy combined with acne therapeutic apparatus in the treatment of moderate to severe acne,so as to provide theoretical basis and an advantage scheme for the treatment of moderate to severe acne.Methods:Patients with moderate to severe acne who were admitted to the dermatology Department of the First Affiliated Hospital of Gannan Medical College from January 2022 to June 2022 were selected and divided into three groups by random number table method: The first group was photodynamic therapy group,with 17 patients,including 9 males and 8 females,with an average age of 20.65±4.11 years.Photodynamic therapy alone was used once a week for 3 consecutive times.The second group was the acne treatment instrument group,with 26 patients,including 14 male patients and 12 female patients,with an average age of 21.54±3.98 years old.They were treated with acne therapy instrument alone,once a week,3 times consecutively.The third group was the combined treatment group,with 15 patients,including 8 male patients and 7 female patients,with an average age of 20.73±3.53 years.The patients were treated with acne therapy instrument and then photodynamic therapy,once a week,for 3 consecutive times.The number of facial lesions(acne,papules,pustules,nodules,cysts)and adverse reactions of patients were recorded before treatment,at week 1,week 2,week 3 and week 4,and the data were analyzed statistically.Results:There was no significant difference in the basic data of the three groups(p>0.05);Before treatment,there were no significant differences in acne,papules,pustules,nodules and cysts among the three groups(P>0.05).After three treatments,there were statistically significant differences in the reduction of acne,papule,pustule,nodules and cysts in the photodynamic treatment group,acne treatment instrument treatment group and combined treatment group(P <0.05).The photodynamic treatment group(total effective rate 47.06%),acne therapy group(total effective rate 100%)and combined treatment group(total effective rate 100%),the total effective rate of three groups was statistically significant(P < 0.05).There were statistically significant differences in the rate of skin loss among the three groups at different treatment times(P<0.05).The combined treatment group had better efficacy than the photodynamic treatment group and the acne treatment instrument group.The changes of the total number of acne,papules,nodules,cysts and skin lesions in the three groups before and after treatment were compared.There was an interaction effect between the groups and time,indicating that the changes of the total number of acne,papules,nodules,cysts and skin lesions at each time point were statistically significant(P<0.05).The number of pimples,papules,nodules,cysts,and lesions decreased more significantly in the combined treatment group than in the photodynamic and acne therapy groups.Conclusion:Photodynamic therapy alone,acne therapy alone and photodynamic therapy combined with acne therapy have therapeutic effects on moderate and severe acne.The efficacy of photodynamic therapy combined with acne treatment instrument is better than that of photodynamic therapy alone.The combination of photodynamic therapy and acne therapy is faster and shorter than photodynamic therapy and acne therapy alone.The combination of photodynamic therapy and acne therapy instrument in the treatment of moderate and severe acne has rapid effect,good efficacy and high safety,which is worth popularizing in clinical application.