Clinical Application Study Of Platelet-Lymphocyte-Ratio In Peritoneal Dialysis-Associated Peritonitis

Objective: To investigate the correlation between platelet to lymphocyte ratio(PLR)and treatment failure in patients with peritoneal dialysis-associated peritonitis(PDAP).Methods: The 136 patients who met the clinical PDAP diagnostic criteria and were hospitalized in the Department of Nephrology of Wuhan Central Hospital from January 2018 to October 2022 were selected as the study subjects.Collecting demographic、clinical and laboratory examination data of the patients,According to the clinical outcome of PDAP,the study subjects were divided into treatment success group and treatment failure group.The general data and relevant clinical clinical information of the two groups were compared.The relationship between PLR values and treatment failure of PDAP was investigated by multivariate logistic regression analysis,and the receiver operating characteristic curve(ROC)was plotted to analyze the predictive value of PLR on treatment failure of PDAP patients.Results: A total of 221 PDAP cases occurred in 136 PD patients.compared with the successful treatment group,PLR 、 NLR and platelet levels were significantly increased in the failed treatment group,with statistically significant differences(P<0.05),while serum albumin and lymphocyte count levels were significantly decreased,with statistically significant differences(P<0.01).Multivariate logistics regression analysis showed that PLR(per100)(OR,2.419,95%CI,1.748-3.346,P<0.001)、 Na(OR,0.856,95%CI,0.768-0.952,P=0.004)were independent risk factors for PDAP treatment failure.ROC curves showed that PLR was a predictor of treatment failure in PDAP patients(cut-off value of 341,AUC=0.803,95%CI,0.720-0.886,P<0.001).Conclusions: PLR and serum sodium are independent risk factors for PDAP treatment failure,and PLR is a new for the occurrence of adverse outcomes in PDAP as a routine test,which is economical and convenient.