| Objective:Through the early use of neoactive in patients with complete STEMI coronary occlusion,myocardial reperfusion level,cardiac function,inflammation,adverse events and other indexes were observed,the effect,prognosis and safety of early use of neoperfusion injury(MIRI)on myocardial ischemia-reperfusion injury(MIRI)were discussed.Methods:1.Using clinical experimental research,80 STEMI patients were continuously selected from March 2022 to November 2022 in the Department of Cardiology of the First Affiliated Hospital of Dali University,and the contrast results that strictly met the inclusion criteria and exclusion criteria showed that the criminal’s blood vessels were completely occluded.2.According to whether neoactive was used early before vascular opening,it was randomly divided into neoactive group(45 cases)and control group(35 cases),and the general data,postoperative reperfusion level,cardiac function,inflammation,renal function,adverse cardiovascular events and other indicators of the two groups were compared.3.Taking the ca IMR value of 40 U as the cut-off value,all patients were divided into non-MIRI group(<40U)and MIRI group(≥40U),and the general data of the two groups of patients were compared to find the risk factors of MIRI.Results:1.There was no significant difference in baseline and interventional data between the two groups(P>0.05).2.Evaluation index of myocardial reperfusion: the mean ca IMR of the neoactive group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05);the difference between ca FFR and ECG STR was not statistically significant(P>0.05).3.Cardiac function indexes: There was no significant difference between LVEDD,LVESD,EF and the difference between the two groups during hospitalization and 1month after surgery(P>0.05).4.Serological indexes: compared between the two groups,there was a statistical difference between BNP and Δ BNP for the first time(P<0.05);Intra-group comparison: NT-pro BNP,CKMB,IL6 and PLR were statistically significant in the neoactive group(P<0.05),and BNP and CKMB in the control group were statistically significant(P<0.05).5.Safety indexes: there was a significant difference in heart rate immediately after surgery between the two groups(P<0.05),and there was no significant difference in preoperative and postoperative heart rate,preoperative,immediate postoperative and1-day postoperative blood pressure,renal function,length of hospitalization and MACE events during hospitalization(P>0.05).6.Comparing the general data of non-MIRI group and MIRI group,the MIRI group had high body mass index,and the difference was statistically significant(P<0.05);The general data variables were included in the binary logistic regression for MIRI influencing factor analysis,and the results showed that neoactive use and lateral branch circulation were independent protective factors affecting MIRI.Hypertension is an independent risk factor for MIRI.Conclusions:1.Early use of neoactive in patients with complete coronary occlusion of STEMI can reduce ca IMR value,improve myocardial microcirculation perfusion level,and reduce postoperative MIRI of PCI.2.Early neoactive use can reduce the levels of BNP,NT-pro BNP,IL6 and PLR in patients after surgery,improve patients’ cardiac function and reduce inflammatory response.3.Early use of neoactive hormone did not increase the renal function impairment,did not extend the hospital stay,did not increase the incidence of hospitalization and MACE in 1 month after surgery,and the early use of neoactive hormone for patients with complete STEM coronary occlusion was safe and reliable.4.The use of neoactive elements and lateral branch circulation are the protective factors affecting MIRI;High body mass index and hypertension are independent risk factors for MIRI. |
PDF Full Text Request