| Background:The anterior cruciate ligament(ACL)is an important ligament structure that maintains the stability of the knee joint,and rupture of the ACL is often combined with damage to the cartilage of the knee joint.Reconstructing the stability of the ligament without addressing the combined articular cartilage damage is not sufficient for these patients,which can lead to the development of secondary osteoarthritis in the long term and reduce the quality of life of the patient.Existing studies have found that platelet-rich plasma(PRP)can help reduce pain,improve knee function,and aid in articular cartilage repair.However,there is little objective clinical evidence directly demonstrating that PRP can help with articular cartilage repair.We treated combined articular cartilage injuries with PRP cavity injections after ACL reconstruction,and compared its efficacy in reducing pain and improving function with cavity injections of hyaluronan(HA),and compared preoperative and postoperative cartilage conditions with magnetic resonance imaging(MRI)of the knee.The cartilage condition of the knee was compared with that of the treated knee by magnetic resonance imaging(MRI).Objective: 1.to investigate the clinical efficacy of PRP in patients with combined cartilage injury after ACL reconstruction by comparing it with the commonly used clinical drug HA.2.to investigate the role of PRP in helping to repair damaged articular cartilage.Methods: A total of 63 patients treated in our department for ACL fracture combined with cartilage injury from January 2021 to August 2022 were included in the retrospective analysis.According to the different treatment regimens after ACL reconstruction,they were divided into 1.HA group with HA injection into the joint cavity as the treatment regimen,with a total of 31 cases;and 2.PRP group with PRP injection into the joint cavity as the treatment regimen,with a total of 32 cases.The efficacy of the two treatment regimens at each stage was evaluated comprehensively by comparing the WOMAC scores and VAS scores before surgery and at five follow-up visits at 1 month,2 months,3 months and 6 months after treatment,as well as comparing and analyzing the cartilage condition under MRI of the knee joint before surgery and at 6 months after treatment.Results : Patients in both groups completed all treatments and obtained a 6-month follow-up.The differences in VAS scores and WOMAC scores were statistically significant(P < 0.05)in both groups after treatment compared with those before surgery,and there was no statistically significant difference(P > 0.05)between the two groups in cartilage Recht grading before surgery and at 6 months of treatment,before and after grade information.In the HA group,the VAS score was lower than that before surgery at 1,2,3 and 6 months of treatment,and the difference was statistically significant at 2,3 and 6 months(P < 0.05),and there was no statistically significant difference between3 and 6 months of treatment(P > 0.05);the WOMAC score was lower than that before surgery at 1,2,3 and 6 months of treatment,and all of them were statistically different(P < 0.05).In the PRP group,VAS scores were lower at 1,2,3 and 6 months of treatment than before surgery,and the difference was statistically significant(P < 0.05)at 2,3 and 6 months,and the difference was statistically significant(P < 0.05)when compared between 3 and 6 months after treatment,and WOMAC scores were lower at 1,2,3 and 6 months of treatment than before surgery,and there was a statistical difference(P < 0.05).The VAS scores at follow-up after treatment were all lower in the PRP group than in the HA group,and the differences were statistically significant at 2,3 and 6months of treatment(P < 0.05);the WOMAC scores at follow-up after treatment were all lower in the PRP group than in the HA group,and the differences were all statistically significant(P < 0.05).Conclusion:1.PRP improves the clinical symptoms of patients with combined cartilage injury after ACL reconstruction better than HA.2.PRP improves the clinical symptoms of patients with combined cartilage injury after ACL reconstruction in a more durable manner than HA. |
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