Analysis Of Hr-HPV Infection And Influencing Factors Of Cervical Cancer Screening Population In Rural Areas Of Xinjiang From 2016 To2020

Object:Taking the screening population of cervical cancer in Yanqi County and Aksu City as an example,the status and distribution of hr-HPV infection among rural women aged 35-64 in Xinjiang from 2016 to2020 were analyzed,and the influencing factors of hr-HPV infection among local women were explored.Methods:The research data is sourced from the National Maternal and Child Major Project Information Direct Reporting System and paper case studies.Historical data on cervical cancer screening among rural women who participated in HPV testing programs from January 2016 to December 2020 were collected,and ultimately 19514 women were included,with an average age of 46.21±7.18 years old.Screening was carried out in accordance with the high-risk HPV subtype detection process of the National Rural Women’s Cervical Cancer Screening Project.HPV detection was carried out through primary screening,cervical cytology,and then transferred to colposcopy and pathological biopsy;Use paper cases to obtain relevant epidemiological information.Describe the infection rate of hr-HPV,the detection rate of cervical cancer or precancerous lesions and the distribution of hr-HPV infection among rural women in the two places;Through the univariate and multivariate analysis of the binary logistic regression model,the relationship between the demographic characteristics,past history,pregnancy and childbirth history and the hr-HPV infection of the cervical cancer screening population was explored.Results:A total of 1415 cases（7.25%）of hr-HPV infection were detected in cervical cancer screening in the two places.A total of 28 cases（133.12/100000）of precancerous lesions were detected in histopathology,and 3 cases（22.19/100000）of cervical cancer were detected.29 cases were diagnosed early,with an early diagnosis rate of 93.55%.Among the screening objects,the infection rate of hr-HPV in Yanqi County（9.54%）was higher than that in Aksu City（6.24%）,the difference was statistically significant（χ²=67.480,P<0.001）.The HPV infection rate of 55-59 years old group and 60-64 years old group was the highest（9.48%）,with a statistically significant difference（χ²=25.339）.The results of univariate analysis showed that region,age,previous screening history,genital tract infection,trichomonal vaginitis,pregnancy times,birth times,abortion times,whether contraception and contraceptive method were the possible influencing factors of hr-HPV infection.The above screened influencing factors were included in the two-classification multi-factor logistic regression model,and the results showed that the risk of hr-HPV infection among rural women in Aksu City was lower than that of rural women in Yanqi County（OR=0.500,95%CI:0.429-0.584）.Women aged 50 to 54 years（OR=1.341,95%CI:1.083-1.662）,55 to 59 years（OR=2.261,95%CI:1.783-2.866）and 60 to 64 years（OR=2.341,95%CI:1.716 to 3.193）have a higher risk of hr-HPV infection than women aged 35 to 39 years,and the risk of infection is higher with age(χ_trend²=12.233,P<0.001).Women with genital tract infection have a higher risk of hr-HPV infection（OR=3.200,95%CI:2.664～3.843）.Women with 2 to 3 pregnancies（OR=1.946,95%CI:1.309～2.895）and 4 or more pregnancies（OR=2.601,95%CI:1.606～4.212）have a higher risk of hr-HPV infection than women who have not been pregnant or have only been pregnant once;Women with 2 to 3births（OR=0.672,95%CI:0.510～0.886）and 4 or more births（OR=0.318,95%CI:0.223～0.453）have a lower risk of hr-HPV infection than women with 0 to 1 births;Women who use oral contraceptives（OR=1.645,95%CI:1.257～2.152）and condoms（OR=2.024,95%CI:1.255～3.263）have a higher risk of hr-HPV infection.Conclusion:The total infection rate of hr-HPV in 19514 rural women in Yanqi County and Aksu City is basically the same as that in southern Xinjiang during the same period.Among them,the infection rate in Yanqi County is higher than that in Aksu City,and the infection rate of rural women aged 55 and above is higher.We should focus on the screening of cervical cancer for women of this age at the county level.Age≥50 years old,genital tract infection,pregnancy≥2 times and use of oral contraceptives are risk factors for infection of hr-HPV.This result can help the screening project to identify high-risk groups at an early stage and provide reference basis for the prevention of women’s infection with hr-HPV.