Objective: By adopting modern data mining methods and technologies,the drug rules of emotional diseases in the Ming and Qing dynasties are mined and summarized,it provide theoretical guidance for the clinical treatment of emotional diseases,and provide new scientific research ideas and methods for related traditional Chinese medicine research.Methods: Through the entry and sorting of prescription drugs for the treatment of emotional diseases in medical cases in the Ming and Qing dynasties,after standardizing and classifying the drug database,the frequency of drugs and their four qi and five flavors,the analysis of association rules,the construction of complex networks of traditional Chinese medicines and the discovery of complex network communities were carried out,and the commonly used drugs,drug groups and their core formulas in the Ming and Qing dynasties were obtained.Results: This study included 523 emotional disease evidence in the Ming and Qing dynasties,involving 350 kinds of drugs.From the distribution of four gases,the frequency reached 1752 times,followed by warm drugs,the frequency reached 1613 times;From the perspective of the distribution of five flavors,the highest frequency of use was sweet medicine,up to 2550 times(34%),bitter medicine was 2295 times(30%),and spicy medicine was 1664 times(22%).association rules and correlation analysis;16 sets of drug pairs were obtained;a complex network was constructed taking into account the correlation degree and drug properties of drugs,and 32 communities were obtained by using the overlapping community discovery algorithm.Conclusion: During the Ming and Qing dynasties,the drugs for emotional diseases were mainly cold and warm,and were more closely related to the five internal organs,and the drugs used more frequently were mainly to replenish qi,nourish blood and revitalize the blood,calm the mind and calm the mind.The core medicine is not too hard to disperse the white peony-angelica blood and not to disperse,but not to reap the acid;Sour jujube kernelFu Shen calms the mind;Ginseng-Poria strengthens the spleen and invigorates qi,and is beneficial in tonifying;Half-summer-Poria wet has no gathering,phlegm can not grow;Frankincense-myrrh activates blood circulation and dissolves stasis;Yanhusuo-Sichuan neem Zi can relieve qi and liver,activate blood and relieve pain;Pearl-bezoar calms the mind;Gentian-aloe vera clear heat diarrhea liver.Among the 7 core prescriptions,the club with Zhuo Ling as the core supports Yuanyang and Lishui Ningxin;The community with Chen Pi as the core plays the gong of qi together;Associations with Banxia as the core and Huangbai as the core replenish the spleen and stomach,raise the spleen and stomach yang qi and reduce the yin fire;The community with Chai Hu as the core relieves the liver and depression,nourishes the mind and calms the mind;A community with ginseng as the core,calming the mind and mind,invigorating qi and nourishing blood;The community with Rehmannia as the core activates blood and dissolves stasis,relieves pain and rationalizes qi. |