Correlation Between Serum Galectin-3 And Prognosis Of Acute Ischemic Stroke

Objective: To investigate the correlation between serum Galectin-3 and the prognosis of Acute Ischemic Stroke(AIS),thus contributing to the early diagnosis and treatment of Post-stroke Cognitive Impairment(PSCI),Post-stroke Anxiety(PSA),and Post-stroke Depression(PSD).Methods: Patients with AIS and outpatient health checkups attending the Department of Neurology,First Affiliated Hospital,Shihezi University School,were selected from October 2021 to May 2022.Patients with AIS were assessed for neurological deficits using the National Institutes of Health Stroke Scale(NIHSS)score on day 1 and day 7 after admission;after day 7 of admission,patients with AIS were assessed for cognitive impairment using the Montreal The cognitive function of the patients was assessed by the Montreal Cognitive Assessment Scale(MOCA),the anxiety status of the patients was assessed by the Hamilton Anxiety Scale(HAMA),and the depression status of the patients was assessed by the Hamilton Depression Scale(HAMD).Independent sample t-test,non-parametric test,X2 test,Pearson test correlation analysis,logistic regression analysis,Receiver Operating Characteristic(ROC)curve analysis,and other methods were used for data analysis.Result:1.Among 493 diagnosed AIS patients,98 AIS patients who met the inclusion criteria of this study were finally included,and the AIS patients were divided into the PSCI group(43 cases)and PSNCI group(55 cases)according to MOCA score,the AIS patients were divided into PSA group(43 cases)and PSNA group(55 cases)according to HAMA score,the AIS patients were divided into PSD group(32cases)and PSND group(66 cases)according to HAMD score;62 cases were selected as the healthy control group during the same period in our hospital.2.Comparison of general data between the AIS group and control group: white blood cell count,neutrophil count,neutrophil count/lymphocyte count ratio(GLR),platelet count/lymphocyte count ratio(PLR),and serum Galectin-3 levels were higher in AIS group than the control group on day 1 after admission,and platelet count/white blood cell count(PWR)was lower than the control group,which was statistically significant(P< 0.05).3.The mean difference of NIHSS score changes between day 1 and day 7 after admission of AIS patients was 1.74±2.375;the changes in biochemical indicators showed that neutrophil count,neutrophil count/lymphocyte count ratio(GLR),and serum Galectin-3 levels decreased on day 7 after admission compared with day 1,which was statistically significant(P<0.05)The mean difference in the change of serum Galectin-3 levels was 33.09±74.76 μg/L.Elevated serum Galectin-3 levels were positively correlated with infarct volume and severity of neurological deficits(P<0.05),and the area under the ROC curve for serum Galectin-3 levels to predict the occurrence of severe neurological deficits in AIS patients was 0.730[95% Confidence Interval(CI),0.631 to 0.829],with an optimal cut-off value of 2373.715 μg/L,sensitivity of 72.3% and specificity of 64.1%.4.The detection rate of PSCI was 43.88%,and the detection rate of PSCI increased with the increase of serum Galectin-3 levels,and the serum Galectin-3 levels of the PSCI group was higher than that of the PSNCI group,and the difference was significant(P=0.004);using Pearson correlation analysis,serum Galectin-3 levels were negatively correlated with MOCA score,attention score,delayed memory score,orientation(P<0.05).Advanced age and increased serum Galectin-3 levels were the risk factors for PSCI.The area under the ROC curve for serum Galectin-3 levels to predict the occurrence of PSCI was0.661[95% Confidence Interval(CI),0.553 to 0.770],with an optimal cut-off value of 2367.5 μg /L,with a sensitivity of 81.4% and specificity of 54.5%.5.The detection rate of PSA was 44.33%,and age,arrhythmia,smoking history,treatment method,and poor prognosis were associated with the occurrence of PSA(P<0.05).6.The detection rate of PSD was 32.95%,and the detection rate of PSD increased with the increase of serum Galectin-3 levels,and the serum Galectin-3 levels in the PSD group was higher than that in the PSND group,and the difference was significant(P<0.001);using logistic multi-factor regression analysis,it showed that poor prognosis and elevated serum Galectin-3 levels were risk factors for the occurrence of PSD;serum Galectin-3 levels predicted the occurrence of PSD with an area under the ROC curve of0.719[95% Confidence Interval(CI),0.618 to 0.819],an optimal cut-off value of 2385.33 μg/L,a sensitivity of 78.1% and a specificity of 65.2%.Conclusion:1.Serum Galectin-3 is closely associated with AIS,and Elevated serum Galectin-3 levels are positively correlated with the severity of neurological impairment and infarct volume,which can be used as a clinical biomarker to predict the prognosis of AIS.2.Serum Galectin-3 is associated with PSCI,elevated serum Galectin-3 levels are the risk factor for the occurrence of PSCI.Serum Galectin-3 levels are negatively correlated with the total score of MOCA and the score of attention,delayed memory,and orientation ability,and Serum Galectin-3 levels are of value in predicting the occurrence of PSCI.3.Serum Galectin-3 is associated with PSD,elevated serum Galectin-3 levels are the risk factor for the occurrence of PSD,and Serum Galectin-3 levels are of value in predicting the occurrence of PSD.