Study On The Correlation Of Post-storke Sleep Disorder With Plasma Uric Acid And Homocysteine Levels

Objective: To investigate the correlation and predictive value of post-stroke sleep disorder with plasma uric acid and homocysteine levels.Methods: In this study,201 stroke patients who met the enrollment criteria were collected from December 2021 to September 2022 at the Department of Neurology,Jilin Provincial People’s Hospital.After admission,the general data collected for the enrolled patients included their gender,age,BMI,NIHSS score,educational level,site of stroke lesion,and past history(smoking,drinking,hypertension,diabetes,and coronary heart disease).In addition,for the enrolled patients,venous blood was drawn 12 hours after fasting after admission,and plasma uric acid and homocysteine levels were collected.The Pittsburgh sleep index was assessed at 10 days of the onset of stroke,and was divided into sleep disorders(PSQI≥7points)and non-sleep disorders(PSQI<7points).Finally,SPSS21.0software was used to analyze the general data and plasma uric acid and homocysteine levels,and p<0.05 was considered statistically significant.Results:1.The incidence of sleep disorder after stroke was 45.3%.2.The general data between the two groups,gender,smoking history,hypertension,coronary heart disease and NHISS,there were statistical differences in the score and stroke site(p <0.05).3.The overall mean of PSQI values varied significantly between the two groups(p<0.05).4.The overall mean difference of plasma uric acid and homocysteine levels between the two groups was significant(p <0.05),which was statistically significant.5.Plasma uric acid(r=-0.448,p <0.01)was negatively correlated with PSQI,while homocysteine(r=0.233,p <0.01)was positively correlated with PSQI.6.Multivariate regression analysis of the two groups reached the conclusion: plasma uric acid(OR=0.990 p=0.002)p <0.05,plasma homocysteine(OR=1.043 p=0.047)p<0.05,smoking history(OR=2.888 p=0.011)p <0.05,NHISS score(OR=1.372 p=0.000)p<0.05.7.The ROC analysis of post-stroke sleep disorders concluded that the area under the ROC curve of plasma uric acid was 0.736,p<0.05.The area under the ROC curve of plasma homocysteine was 0.673,p <0.05.Conclusion:1.Sleep disorders after acute stroke have a higher morbidity rate.2.Smoking history,hypertension,coronary heart disease,NHISS score,and stroke site are the influencing factors for post-stroke sleep disorders.Plasma uric acid is a protective factor for post-stroke sleep disorder,and plasma homocysteine is a risk factor for post-stroke sleep disorder.3.Plasma uric acid and homocysteine levels are important for predicting post-stroke sleep disorders.