Correlation Between Osteoporosis And Sarcopenia In Middle-aged And Elderly Patients With Type 2 Diabetes Mellitus

Objective:This study collects clinical data to explore the association between osteoporosis(OP)and sarcopenia(SP)in middle-aged and elderly patients with type 2 diabetes mellitus(T2DM).Methods:In this cross-sectional study,181 middle-aged and elderly patients(aged 50-80 years)with type 2 diabetes mellitus who were hospitalized in our hospital from January2021 to September 2022 were selected as study subjects,and general clinical data were collected from the patients.The patients’ general clinical data were collected,bone mineral density(BMD),skeletal muscle mass index(ASMI),and grip strength were measured,and the subjects were divided into the osteoporosis group(63 cases in the OP group)and the non-osteoporosis group(118 cases in the non-OP group)and the sarcopenia group(34 cases)and the non-sarcopenia group(147 cases)according to the diagnostic criteria of BMD and sarcopenia,respectively,and the differences in general data and muscle content between the OP and non-OP groups were compared.The differences between the OP and non-OP groups in terms of general information and muscle content were compared;the differences in clinical indicators and bone density between the myasthenia gravis and non-myasthenia gravis groups were also analyzed,and the correlation between bone density and skeletal muscle mass(ASM),skeletal muscle mass index(ASMI),grip strength and body fat content of the extremities was analyzed by correlation.Further logistic regression was used to analyze the risk factors of sarcopenia.Results: 1.Among the 181 middle-aged and elderly T2 DM patients included in this study,age and body mass index(BMI)were statistically different in the OP group compared with the non-OP group,with the OP group being older and having a lower BMI(P < 0.05)(both P < 0.05).2.The prevalence of sarcopenia was significantly higher in the OP group than in the non-OP group(31.8% vs.11.9%),with a statistically significant difference(P <3.grip strength,ASM and ASMI were lower in the OP group than in the non-OP group,with statistically significant differences(P < 0.05).4.lumbar spine BMD and left and right femoral neck BMD were significantly lower in the sarcopenia group than in the non-sarcopenia group,with statistically significant differences(P < 0.05),and the prevalence of osteoporosis was(58.8% and 29.2%)in the sarcopenia and non-sarcopenia groups,respectively The difference was statistically significant(P < 0.05),and Pearson correlation analysis showed that BMD was significantly correlated with muscle mass of the skeletal muscles of the limbs,age,ASMI and muscle strength,with a positive correlation with ASMI and a negative correlation with age.5.BMI(OR = 0.909,P = 0.01)was a protective factor for the development of sarcopenia,and age(OR = 1.053,P = 0.01),duration of diabetes(OR=1.375,P=0.004),and osteoporosis(OR=3.921,P=0.001)were risk factors for the development of sarcopenia.Conclusion: 1.The prevalence of sarcopenia was high in middle-aged and elderly patients with type 2 diabetes mellitus combined with osteoporosis,while the prevalence of osteoporosis was higher in patients with sarcopenia.2.BMD was positively correlated with ASMI and negatively correlated with age.3.Age,disease duration,and osteoporosis were risk factors for the development of sarcopenia,and BMI was a protective factor for the development of sarcopenia.