Effect And Prognosis Of Serum Uric Acid Cardiovascular Events In Patients After PCI With Acute Coronary Syndrome

Objective:To investigate the effect of serum uric acid level lowering therapy on major adverse cardiovascular events in patients with acute coronary syndrome after PCI and assess the prognosis.Methods:This study collected 265 patients with acute coronary syndrome complicated with hyperuricemia who underwent PCI from December 2017 to December 2018 in the first people’s hospital of Yunnan province,and divided patients into the treatment group and the control group according whether they were treated with serum uric acid lowering therapy or not.Collected general clinical data,biochemical indexes,cardiac ultrasound,coronary angiography and other data before and after treatment and followed up major adverse cardiovascular events for 2 years.Compared and analyzed changes of various indexes before and after treatment.Results:1.There was no significant difference in general baseline data between two groups(P>0.05).2.Compared with the control group,serum uric acid、high-sensitivity troponin T、pro-BNP、CRP、LAD、LVEDD、LVESD、SV、EFand Gensini score in the treatment group were significantly difference after treatment(P<0.05).The scatter plot between serum uric acid and each index showed that there was a correlation between serum uric acid level and Gensini score,with the correlation coefficient R~2>0.6,(P<0.05).3.The incidence rate of major adverse cardiovascular events in the treatment group was lower than the control group[25(21.2%)VS 44(29.9%),P<0.05]and the survival rate without MACEs was higher than the control group[93(78.8%)VS 103(70.1%),P<0.05].Logistic regression analysis showed that hyperuricemia was anindependent risk factor for major adverse cardiovascular events after treatment[OR=2.553,95%CI(1.322-2.952),P<0.05].4.Multivariate ROC curve showed that serum uric acid level was a strong predictor of MACEs,with Jordan index of 0.509,sensitivity of 0.806,specificity of 0.703,critical value of468umol/L(P<0.05).Conclusions:Hyperuricemia is an independent risk factor for MACEs in patients with acute coronary syndrome after PCI.Serum uric acid level lowering therapy can significantly reduce the occurrence of MACEs in patients with acute coronary syndrome after PCI,which is expected to be a new method to improve the prognosis of patients in the future.