| Objective This topic is under the guidance of the theory of "women’s meridian regulation" as the necessary condition of pregnancy physiology in traditional Chinese gynecology,to give Yangrong decoction intervention treatment to the patients with thin endometrium infertility of spleen and kidney deficiency type before entering IVF-ET(in vitro fertilization and embryo transfer),to strengthen the spleen and kidney,replenish the deficiency,regulate the meridian and promote pregnancy.At the same time,a control group was set up to systematically observe the changes of endometrial thickness and menstrual volume of patients with thin endometrium infertility of spleen and kidney deficiency type before entering IVF-ET,as well as the pregnancy status of patients after entering IVF-ET,and the pregnancy rate of patients in the two groups was counted.Methods Collecting 86 cases were randomly divided into observation group(N = 44)and control group(N = 42).The patients in both groups were treated with drugs for 3months before the transplantation cycle.The patients in the observation group were given fenmaron tablets orally from the 3rd day of menstruation before the transplantation cycle,one tablet per day,after taking 28 days to stop the next menstrual period after the third day to take the law,take 3 menstrual cycles,at the same time in the second day of menstrual clean yangrong Tang 16 days to take 3menstrual cycles;The control group only took Fenmoton orally,the method and time of taking were the same as the observation group.E2(estradiol),LH(Lutropin alfa)and p(progesterone)levels were recorded on the day of HCG(human chorionic Gonadotropin)or luteal support before the transplantation cycle After the third menstrual cycle,the endometrial thickness and types of the two groups,the level of HCG in the blood of the blastocyst on the 14 th day after transplantation,the level of E2,P,HCG and the color Doppler ultrasound of the vagina on the 30 th day after transplantation were followed up.The endometrial thickness,type,amount of menstruation and post-transplantation pregnancy of the two groups were observed and the clinical data were analyzed.Results1.In the Observation Group,there were 14 cases of pregnancy,5 cases of abortion and 4 cases of biochemistry in 22-30 years old,14 cases of pregnancy,3 cases of abortion and 1 case of biochemistry in 31-35 years old There were 28 cases of pregnancy(63.6%)and 16 cases of non-pregnancy(36.4%).In the control group,there were 16 cases of pregnancy,2 cases of abortion and 3 cases of biochemistry in22-30 years old,6 cases of pregnancy,6 cases of abortion and 5 cases of biochemistry in 31-35 years old,1 case of pregnancy over 36 years old,2 cases of abortion and 1case of biochemistry There were 23 cases of pregnancy(54.8%)and 19 cases of non-pregnancy(45.2%).There was no significant difference between the two groups(P= 0.338 >0.05)in the pregnancy rate between 22-30 years old(P=0.554>0.05)and older than 36 years old(P=0.010 <0.05),there was no significant difference in the total pregnancy rate between the two groups(P=0.402> 0.05),indicating that there was no significant difference in the total pregnancy rate between the two groups.2.The curative effect of thin endometrium was compared between the two groups,8cases(18.2%)were cured in the observation group,22 cases(50%)were markedly effective,8 cases(18.2%)were effective,6 cases(13.6%)were ineffective,4 cases(9.5%)were cured in the control group,and the therapeutic effect of thin endometrium was better in the observation group than in the control group,14 cases(33.3%)were markedly effective,13 cases(30.9%)were effective,11 cases(26.2%)were ineffective,P= 0.032 < 0.05,indicating that the observation group was superior to the control group in improving the thin endometrium.Further comparison showed that the therapeutic effect of thin endometrium in patients aged 22-30 years(P=0.318 > 0.05),31-35 years(P=0.066> 0.05),and over 36 years(P=0.445>0.05)were all P>0.05;No statistical difference,indicating that Yangrong decoction combined with Fenmaitong improve thin endometrium of patients with no age difference in the efficacy.3.Before treatment,there were 34 cases of type C,9 cases of type B-C,1 case of type B,0 cases of type B-A,0 cases of Type A in the observation group,30 cases of Type C,12 cases of type B-C,0 cases of type B in the control group,there were 0 cases of type B-A and 0 cases of type A,P= 0.584 > 0.05.There was no statistical significance.Before and after treatment,there were 1 case of C type,2 cases of B-C type,3 cases of B type,12 cases of B-A type,26 cases of a type in the observation group,6 cases of C type and 3 cases of B-C type in the control group,there were 7 cases of type B,9cases of type B-A and 17 cases of type A.there were significant differences between the two groups(P<0.05),there was significant difference between the two groups(P=0.02<0.05),indicating that the therapeutic effect of the observation group was better than that of the control group.4.After treatment,the endometrial thickness of the two groups was significantly thicker than that before treatment(P< 0.05),there was significant difference between the two groups(P= 0.012 < 0.05),the results showed that the increase of endometrial thickness in the observation group was superior to that in the control group.5.HCG(P= 0.002<0.05)and E2(P=0.006 <0.05)were significantly different between the two groups 30 days after transplantation(P=0.006< 0.05),there was no significant difference between the two groups(P= 0.762 >0.05)6.There was significant difference between the two groups after treatment(P=0.00<0.05).It showed that the menses volume of the two groups were improved after treatment,the symptoms of menorrhagia in the observation group were significantly improved than those in the control group(P=0.00<0.05),indicating that the combination of Yangrong decoction and Fenmaitong has a better effect on menorrhagia in patients with thin endometrium than Fenmaitong alone.7.After treatment,intra-group comparison showed that the symptoms of less menstruation,less gas and lazy speech,abdominal distension after eating,sore waist and knees,dizziness and tinnitus,less appetite,clear and long urine,and loose stool in the observation group were improved compared with those before treatment(P<0.05).There was no statistical difference between the other syndromes(P>0.05);After treatment,the observation group had less menstruation(P<0.05),other symptoms have no significant differences between two groups(P>0.05).dark and thin menstruation,less gas and lazy speech,abdominal distension after eating,sore waist and knees,less appetite,clear and long urine,loose stool(P<0.05),and no significant difference in symptoms of anorexia and heel pain(P>0.05),which showed that Yangrong decoction and Fenmotong could improve the menstrual status of patients in both groups,but Yangrong decoction improved other symptoms of patients,such as sore waist and knees The symptoms such as dizziness and tinnitus were significantly better than those of Fenmotone alone,while the symptoms of sexual desire reduction and heel pain were not significantly improved in the two groups.ConclusionBefore thin endometrial infertility patients entered IVF-ET,Yangrong Decoction combined with Fenmotiong was used to intervene for three menstrual cycles;1.It can promote endometrial thickening,and the curative effect is better than that of Fenmotiong alone.2.It can promote the transformation of endometrial morphology from type C to type A,which is more suitable for embryo implantation,and the curative effect is better than that of Fenmotiong alone.3.It can improve the menstrual flow of patients before entering IVF-ET,and the curative effect is better than that of Fenmotiong alone.4.It can improve the pregnancy rate of patients aged 31-35,and the curative effect is better than that of Fenmotiong alone,but it has no significant effect on the pregnancy rate of patients aged 22-30 and over 36. |
PDF Full Text Request