| Glucose is one of the main sources of energy for human cells.Diabetes is characterized by elevated levels of glucose in the blood.Although there is currently no cure for diabetes,research suggests that strict control of blood glucose levels can improve the survival rate of diabetes patients and prevent complications associated with type 1 and type 2 diabetes.As a result,monitoring blood glucose levels has become an essential part of daily life for diabetes patients and many other patients with various diseases.However,given the cost and universality limitations of enzyme-based glucose sensors and the increasing demand for inexpensive,rapid,and accurate non-enzyme glucose sensors,the development of high-performance non-enzyme glucose sensors is urgently needed.The purpose of this article is to investigate a non-enzyme glucose sensor with a wide detection range,high sensitivity,weak response to other interfering substances,and long-term stability,and to develop a portable glucose detection system based on this sensor.The specific contents include:（1）This study investigates the synthesis method and sensing properties of CuS nanomaterials,and successfully prepares flower-shaped CuS nanoparticles through a hydrothermal method.Analysis of the morphology and phase of the nanomaterials reveals that the flower-shaped structure of CuS provides a large surface area with more active sites and ensures efficient electron transfer.To study the sensing properties of the sample towards glucose,a non-enzyme glucose sensing electrode modified with CuS was prepared,and its electrochemical sensing characteristics were studied.Experimental results demonstrate that the modified electrode exhibits excellent glucose sensing properties.The sensor has a wide linear detection range of 0-5 m M,with a high sensitivity of 2139.04μA m M-1cm-2 and a detection limit of 0.38μM.Furthermore,the modified electrode shows a strong current response within the linear range of 0.001-11 m M and a weak response to other interfering substances in serum,indicating excellent anti-interference properties.These results are very close to normal glucose levels in the human body,demonstrating that the electrode-modified material has excellent electrocatalytic properties and can be a candidate material for electrochemical glucose sensors.（2）This study synthesized a self-assembled flower-shaped core-shell NiS@CuS bimetallic sulfide and investigated its sensing properties.By adjusting the reaction conditions and element ratios,a reactant with a flower-shaped structure was successfully prepared,increasing its specific surface area and chemical activity.The presence of a core-shell structure self-assembled in the solution was confirmed by X-ray diffraction and electron microscopy.The sensing performance of the modified glassy carbon electrode was studied by electrochemical testing.The results showed that the modified electrode had good sensing performance in the linear detection range of 0-6m M,with a high sensitivity of 5876.847μA m M-1cm-2 and a detection limit of 0.35μM.Compared to other non-enzyme glucose sensing electrodes,it had excellent current response in the linear range of 0.001-12m M,as well as good anti-interference ability and stability,making it a promising candidate for clinical non-enzyme glucose detection.（3）This study presents the design of a portable glucose detection system based on electrochemical detection.The system utilizes STM32F103C8T6 as the processing core,featuring a small size,low power consumption,ease of portability,and simple peripheral circuitry.Furthermore,the design and fabrication of the sensor hardware circuitry were completed,and the stability and accuracy were validated through experimental measurements.The results demonstrate that this design can be widely applied in glucose detection for both daily life and medical applications. |
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