Effect Of In Tranterine Infusion Of Platelet-Rich Plasma On Pregnancy Outcome Of F-ET In Patients With Repeated Implantation Failure And Chronic Endometritis

Obj ectiveFor 217 patients with recurr ent implantation failure and chronic endometritis who require freeze-thaw embryo transfer,platelet rich plasma intrauterine perfusion therapy was used to observe their clinical pregnancy outcomes,analyze their embryo implantation rate,clinical pregnancy rate,ectopic pregnancy rate,early miscarriage rate,and live birth rate,and explore the impact of platelet rich plasma intrauterine perfusion on the pregnancy outcomes of freeze-thaw embryo transfer in patients with recurr ent implantation failure and chronic endometritis.MethodThis study retrospectively analyzed the data of patients undergoing frozen-thawed embryo transfer(F-ET)at the Reproduction C enter of Hainan Women and Children’s Medical C enter from January 2021 to February 2022.217 patients were included in the study,which needed to meet the diagnostic requirements of recurr ent implantation failure(RIF)and chronic endometritis(CE)at the same time.According to whether platelet-rich plasma(PRP)intrauterine perfusion intervention was performed in F-ET cycle,the patients were divided into two groups:109 patients in the treatment group(PRP intrauterine perfusion)and 108 patients in the control group.Relevant data such as embryo implantation rate,clinical pregnancy rate,ectopic pregnancy rate,early abortion rate and live birth rate were collected and analyzed.SPSS 25.0 software was used to analyze the data.The measurement data are expressed in M(P25,P75),using Wilcoxcon Mann-Whitney test.The counting data is expressed by the structure rate,using the chi-square test,and Pearson chi-square is selected when n≥ 40 and T≥ 5.When n≥ 40,1 ≤T ≤5,select continuous chi-square test.Binary logistic regression analysis was used to calculate the independent correlation when excluding the influence of confounding factors.In all statistics,p<0.05 is considered statistically significant.Result(1)The early abortion rate in the treatment group was significantly lower than that in the control group(13.2%vs 30.6%),and the difference was statistically significant(p<0.05).(2)The embryo implantation rate,clinical pregnancy rate and live birth rate of the treatment group were 55%,48.6%and 42.4%respectively The rates of the control group were 52.8%,45.4%and 31.5%respectively.Although the embryo implantation rate,clinical pregnancy rate and live birth rate of the treatment group were higher than those of the control group,the difference was not statistically significant(p>0.05).(3)The rate of ectopic pregnancy in the treatment group was lower than that in the control group(1.9%vs 8.2%),but the difference was not statistically significant(p>0.05).(4)After controlling for confounding factors such as age,infertility years,BMI,trigger day endometrial thickness,bAFC,and the number of embryos transferred,the results showed that PRP intrauterine perfusion was independently associated with early abortion in patients with RIF and CE,indicating that PRP intrauterine perfusion was a protective factor for early abortion in patients with RIF and CE(Adjust OR=2.624,CI 1.002-6.871,p<0.05).ConclusionThe use of PRP intrauterine perfusion can significantly reduce the early abortion rate of patients with RIF and CE,thus improving the pregnancy outcome of F-ET in such patients;Although the ectopic pregnancy rate,embryo implantation rate,clinical pregnancy rate and live birth rate in the treatment group are not statistically significant compared with those in the control group,there are differences in data,which may be a clinically significant trend.