| Objective:COVID-19 has been increasing in global incidence and mortality since the outbreak of a novel coronavirus in 2019.meta-analysis has been conducted to explore the relationship between TMPRSS2-rs12329760 gene polymorphism and susceptibility or severity of COVID-19,but the results are inconsistent.Furthermore,these meta-analyses are rarely included in the study,and new studies are currently being published,and the association between the polymorphism of the rs12329760 gene and the death risk of COVID-19 patients is discussed.As a result,the goal of this meta-analysis is to summarize the most recent research evidence,determine whether the association between rs12329760 gene polymorphism and COVID-19(susceptibility,severity,and risk of death)is significant,and provide evidence support for clinical practice in COVID-19.Methods:The retrieval strategy is developed using the PICOS principle and a combination of keywords and free words such as "novel coronavirus","TMPRSS2","polymorphism",and "single nucleotide".Search the following electronic databases in Chinese and English:China Biomedical Discs(CBMdisc),Chinese National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform,VIP Chinese Sci-tech Journals Full-text Database,PUBMED,Embase,Web of Science,Scopus,Ovid,as well as references of meta-analysis and comments published before manual retrieval,the retrieval time range is limited to the establishment of each database so far.According to the inclusion and exclusion criteria,the relevant studies that meet the requirements are screened,and the relevant research data are carefully read and extracted.The data were statistically analysed using the Revman5.3 and R4.1.3 software,and binary variable data were expressed as odds ratios(OR)and 95%CIs.Results:There were thirteen English literatures included,including one cross-sectional study,seven cohort studies,and five case-control studies.The quality of the literature was assessed using the NOS and AHRQ scales.Four of the literatures were of medium quality,while nine were of high quality.Hardy-Weinberg equilibrium was observed in all of the included literatures(HWE).The analysis results are as follows.The polymorphism of TMPRSS2rs12329760 gene and the risk of SARS-CoV-2 infection were analyzed.A total of 8 literatures were included in the meta-analysis:①Allelic model(C vs T)OR=0.89,95%CI=(0.77-1.03),Z=0.56,P=0.12,the difference was not statistically significant;②Dominant model(CC+CT vs TT)OR=0.88,95%CI=(0.08-9.99),Z=0.37,P=0.71,the difference was not statistically significant;③Recessive model(CC vs CT+TT)OR=1.33,95%CI=(0.92-1.91),Z=0.48,P=0.63,the difference was not statistically significant;④Additive model(CC vs CT)OR=0.96,95%CI=(0.84-1.10),Z=0.59,P=0.55,the difference was not statistically significant;⑤Homozygous model(CC vs TT)OR=0.92,95%CI=(0.601.41),Z=0.38,P=0.71,the difference was not statistically significant.The polymorphism of TMPRSS2rs12329760 gene and the severity of novel coronavirus pneumonia were analyzed.A total of 9 literatures were included in the metaanalysis:①Allelic model(C vs T)OR=0.85,95%CI=(0.61-1.18),Z=0.98,P=0.33,the difference was not statistically significant;②Dominant model(CC+CT vs TT)OR=0.91,95%CI=(0.51-1.62),Z=0.33,P=0.74,the difference was not statistically significant;③Recessive model(CC vs CT+TT)OR=0.79,95%CI=(0.53-1.18),Z=1.15,P=0.25,the difference was not statistically significant;④Additive model(CC vs CT)OR=0.79,95%CI=(0.56-1.10),Z=1.42,P=0.15,the difference was not statistically significant;⑤Homozygous model(CC vs TT)OR=0.78,95%CI=(0.381.62),Z=0.66,P=0.51,the difference was not statistically significant.The polymorphism of TMPRSS2rs12329760 gene and the risk of death from novel coronavirus pneumonia were analyzed.A total of 4 literatures were included in the metaanalysis:①Allelicmodel(C vsT)OR=0.59,95%CI=(0.17-2.08),Z=0.82,P=0.41,the difference was not statistically significant;②Dominant model(CC+CT vs TT)OR=0.52,95%CI=(0.14-1.98),Z=0.57,P=0.57,the difference was not statistically significant;③Recessive model(CC vs CT+TT)OR=0.61,95%CI=(0.13-2.91),Z=0.61,P=0.54,the difference was not statistically significant;④Additive model(CC vs CT)OR=0.79,95%CI=(0.56-1.10),Z=1.42,P=0.15,the difference was not statistically significant;⑤Homozygous model(CC vs TT)OR=0.52,95%CI=(0.083.56),Z=0.67,P=0.50,the difference was not statistically significant.Conclusion:Five gene models of TMPRSS2 rs12329760 gene polymorphism,included:Allelic model(C vs T),Dominant model(CC+CT vs TT),Recessive model(CC vs CT+TT),Additive model(CC vs CT),Homozygous model(CC vs TT)were not significantly associated with susceptibility to SARS-CoV-2,severity of COVID-19 and risk of death. |
PDF Full Text Request