Estimating Osteoporotic Hip Fracture Risk In Older Men Using Serum Bone Turnover Markers And Testosterone

Background:Osteoporotic fractures are an important complication of osteoporosis,and hip fractures are the most common cause of death in elderly persons following accidents.Patients with hip fractures frequently lose their ability to live independently,and men are nearly twice as likely as women to perish from hip fractures.In China,the incidence of hip fractures has increased rapidly over the past several years.Testosterone is essential for maintaining bone mass and preventing bone loss,and markers for bone turnover can accurately represent bone metabolism.Additionally,there are currently few domestic studies on the correlation between bone turnover indicators,testosterone,and osteoporotic hip fractures in older males,and the findings of international studies are contradictory.Purpose:To look at the association between testosterone,bone turnover markers,and osteoporotic hip fracture in older men.Methods:The control group included 64 individuals,while the case group included 52 senior male patients with osteoporotic hip fracture who visited the orthopedic clinic or were hospitalized to the First Affiliated Hospital of Chengdu Medical College between March2021 and December 2022.The link between bone turnover markers,testosterone,and osteoporotic hip fracture in older men was investigated using binary logistic regression.The two groups’ overall health,bone mineral density,and bone turnover indicators were contrasted.Result:Age,height,weight,body mass index,smoking/drinking/drinking ratio,and bone density did not significantly vary between the two patient groups.Serum concentrations of β-CTX and PINP were greater in the hip fracture group than in the non-hip fracture group,but testosterone,N-MID,and ALP did not statistically vary between the two groups.In older males,blood levels of β-CTX and P1 NP were positively connected with the development of osteoporotic hip fractures(OR is respectively 4.889 and 2.654;and95% CI is 2.036-11.742 and 1.093-6.444,P<0.05);there was no association with serum levels of N-MID,ALP or testosterone.Conclusion:In this cross-sectional analysis,high serum levels of the bone turnover markers β-CTX and P1 NP were found to be positively correlated with the risk of osteoporotic hip fracture in elderly men,which may be their risk factors.Serum testosterone levels,however,were not found to be associated with this risk.In conclusion,it is proposed that blood levels of β-CTX and PINP in older men with osteoporosis have some clinical value in the identification and management of fragility hip fractures.