Clinical Effect Analysis Of Short-term High Cervical Spinal Cord Stimulation And Pulsed Radiofrequency On Gasserian Ganglion For Zoster Associated Pain In Mandibular Nerve

Objective: To compare the efficacy of short-term high cervical spinal cord stimulation and the pulsed radiofrequency on Gasserian ganglion for treating zoster associated pain in mandibular nerve retrospectively.Methods: Patients with acute or subacute zoster associated pain in the mandibular nerve from October 2017 to June 2022 were recruited,and then divided into 2 groups according to the treatment they had received: Group PRF or Group SCS.The therapeutic effects were evaluated by numeric rating scale(NRS),the daily dosage of Pregabalin,the Pittsburgh sleep quality index(PSQI),the physical component scores(PCS-12)and mental component scores(MCS-12)of 12-item short form health survey questionnaire before the treatment and at 1 week,4 weeks,12 weeks and 24 weeks after treatment,adverse events were also recorded.The data before treatment were obtained from the electronic medical system,and data after treatment were collected through telephone interview and the questionnaire survey.Results: At 1 week,4 weeks,12 weeks and 24 weeks after treatment,NRS,daily dosage of Pregabalin and PSQI were significantly decreased than before treatment respectively(P<0.01),the PCS-12 and MCS-12 were significantly increased than before treatment respectively(P<0.01).At 1 week and 4 weeks after treatment,there was no difference in all the indexes between Group PRF and Group SCS.However,at 12 weeks and 24 weeks after treatment,NRS,the daily dosage of Pregabalin and PSQI in Group SCS were lower than those in Group PRF(P<0.05),PCS-12 and MCS-12 were higher than those in Group PRF(P<0.05).No serious adverse event was observed.Conclusion: Short-term high cervical spinal cord stimulation and pulsed radiofrequency on Gasserian ganglion could significantly alleviate the zoster associated pain in the mandibular nerve,reduce the dosage of analgesic drugs,and improve the quality of sleep and life of patients.The short-term effect of short-term high cervical spinal cord stimulation was not worse than pulsed radiofrequency on Gasserian ganglion,and the long-term effect was better than that of pulsed radiofrequency on Gasserian ganglion.