Analysis Of The Relationship Between Systemic Immune-Inflammation Index And Risk Stratification Of Acute Pulmonary Embolism

Objectives: Pulmonary embolism(PE)is a common cardiovascular disease in clinical practice.Clear diagnosis and timely risk stratification are very important for the prognosis of patients.However,the current stratification criteria are complex and not easy to obtain in the first time.This study aims to analyze the general situation of patients with acute pulmonary embolism(APE)and investigate the association between the systemic immune-inflammation index(SII)and risk stratification of APE.Methods: From January 2019 to October 2022,We retrospectively analyzed clinical data of APE patients who were hospitalized in Shengjing Hospital,affiliated to China Medical University.They were divided into low-risk group(45 cases),medium-low risk group(36 cases),medium-high risk group(37 cases)and high-risk group(28 cases).General data,basic diseases,vital signs and laboratory tests were statistically analyzed.Differences between groups were analyzed,and significant indicators were included in multiple ordered logistic regression to analyze influencing factors.The low-risk group,the medium-risk group and the high-risk group were summarized into the non-low-risk group,and the differences among the groups were analyzed.Binary logistic regression was used to analyze the influencing factors in a meaningful way,and receiver operating characteristic(ROC)curve was drawn.Results: 1.Systolic blood pressure,diastolic blood pressure,heart rate,syncope,WBC,NE,LY,MO and SII were statistically significant(P<0.05).Multiple logistic regression showed that WBC,SII,heart rate and syncope were independent risk factors for stratification(P<0.05).2.Systolic blood pressure,diastolic blood pressure,heart rate,SII,WBC,MO and syncope were significantly different between low-risk group and non-low-risk group(P< 0.05).Binary logistic regression showed that WBC and SII were independent risk factors for low-critical pulmonary embolism(P<0.05).3.The area under the curve(AUC)of SII and WBC in assessing the risk stratification of acute pulmonary embolism were 0.930 and 0.877,respectively.The diagnostic specificity and sensitivity of SII for non-critical pulmonary embolism were 97.78% and 47.52%.The diagnostic specificity and sensitivity of WBC for non-critical pulmonary embolism were 97.78% and 54.46%.Conclusions: SII was significantly different in different risk stratification of patients with acute pulmonary embolism,and increased with the increasing degree of risk stratification,which has certain significance for predicting the stratification of acute pulmonary embolism.Early assessment of SII on admission is conducive to early risk stratification and provides the basis for clinical diagnosis and treatment.