Correlation Analysis Between Plasma CCL17 Level And Parkinson’s Disease

Objective: To investigate the relationship between plasma CCL17 level and clinical characteristics and severity of Parkinson’s disease(PD)patients.At the same time,the differences of clinical manifestations of different clinical subtypes of PD were analyzed.Methods: 50 patients with Parkinson’s disease and 60 healthy controls matched in age and sex were collected from Shengjing Hospital affiliated to China Medical University from 2020 to 2022.General clinical data were collected: age,sex,history of smoking,drinking history,course of disease,history of hypertension,history of diabetes and so on,And special biochemical indexes,plasma CCL17 level.The data of all subjects in PD group were collected,including Unified Parkinson’s Disease rating scale(UPDRS),non-Motor symptom Assessment scale(NMSS),Hamilton Depression scale(HAMD),Hamilton anxiety scale(HAMA),and Hoehn-Yahr rating scale(HY).PD group was divided into postural instability and gait diffificulty(PIGD)and tremor diffificulty(TD)by UPDRS scale;PD group was divided into early group and middle and late group by HY scale;PD group was divided into anxiety group and non-anxiety group by HAMA group.The data were analyzed by t-test,nonparametric test,chi-square test,Spearman correlation analysis,Logistic regression analysis and ROC curve.Results :Between the PD group and the healthy control group,the plasma CCL17 level in the PD group was significantly lower than that in the control group(P < 0.001).The proportion of patients with drinking history in the PD group was significantly higher than that in the control group(P < 0.05).The results of stepwise Logistic regression showed that the CCL17 may be an independent protect factor for PD(OR < 1,P < 0.001),and drinking history may be an independent risk factor for PD(OR > 1,P < 0.05).There was no significant correlation between plasma CCL17 level and related clinical data in patients with PD(P > 0.05).ROC curve analysis showed that plasma CCL17 levels had high sensitivity and specificity in predicting PD occurrence(P<0.001).The score of HY rating scale in PIGD group was significantly higher than that in TD group(P < 0.05).The age,HAMA score,HAMD score,UPDRS,UPDRS Ⅰ,UPDRS Ⅱ,UPDRS Ⅲ and NMSS in the middle and late stage of PD were higher than those in the early stage group(P < 0.05).The course of disease,HY score,HAMD score,UPDRS,UPDRS Ⅰ,UPDRS Ⅱ,UPDRS Ⅲ and NMSS in patients with anxiety in PD were higher than those in non-anxiety group(P < 0.05).Conclusion: The level of plasma CCL17 in patients with PD is significantly lower than that in healthy controls,and it has high sensitivity and specificity for predicting PD in this study.CCL17 has not been found to be related to the progression of PD disease,different exercise types and the occurrence of anxiety.PD patients with abnormal gait and postural dyskinesia usually have severe disease development.In PD patients with severe anxiety and disease development,motor function,non-motor function and self-care ability all decreased in varying degrees,suggesting the importance of early intervention,heterogeneity and individualized treatment.