Analysis Of Influencing Factors Of Slow Flow/no Reflow Phenomenon In Patients With Acute Coronary Syndrome During Percutaneous Coronary Intervention

Objectives:To analyze the related factors of slow flow/no-reflow(SF/NRF)during percutaneous coronary intervention(PCI)in patients with acute coronary syndrome.Methods:Two hundred STEMI patients receiving PCI and Four hundred NSTE-ACS patients receiving PCI were retrospectively analyzed.They were divided into SF/NRF group(TIMI grade ≤2)and non-SF/NRF group(TIMI grade 3)according to the blood flow of the distal coronary artery during operation.The baseline data and interventional related indicators of the two groups were compared,and the influencing factors and independent predictors of SF/NRF were analyzed.Results:Age,diabetes ratio,cardiac function grade 2-3 ratio,cTnI peak,CK-MB peak,LDL-C,D-dimer and fibrinogen of STEMI patients in SF/NRF group were significantly higher than those in SF/NRF group(P<0.05),while invasive systolic blood pressure and invasive diastolic blood pressure were significantly lower than those in SF/NRF group(P<0.05).Multivariate regression analysis showed that LDL-C,D dimer,and fibrinogen were independent predictors of SF/NRF after PCI in STEMI patients.The age,diabetes rate,WBC,NE,TG,TC,LDL-C,stent diameter and length in the SF/NRF group were significantly higher than those in the non-SF/NRF group(P<0.05).Multivariate regression analysis showed that age,white blood cell count,neutrophil count,and LDL-C were independent predictors of SF/NRF in patients with NSTE-ACS during PCI.Conclusions:LDL-C,D-dimer,and fibrinogen are independent predictors of SF/NRF in patients with NSTE-ACS during PCI.Age,white blood cell count,neutrophil count,and LDL-C were independent predictors of SF/NRF in patients with NSTE-ACS during PCI.LDL-C was an independent predictor of SF/NRF in patients with STEMI and NSTE-ACS during PCI,and was superior to other factors in predicting SF/NRF during PCI.