Study On The Onset Time And Pathological Distribution Of Biliary Distension Based On Chronomedicine

Objective: Taking patients with biliary distension disease(acute cholecystitis,acute attack of chronic cholecystitis,etc.)hospitalized in our hospital from January 20,2018 to January 20,2020 as research subjects,a cross-sectional study was conducted to analyze the distribution of main qi,main qi,and solar terms in the onset time of biliary distension disease,To explore the possible relationship between the onset time of biliary distension disease and the five movements and six qi;At the same time,research and analyze the temporal distribution of the onset time of biliary distension disease,and explore the possible relationship between the onset time of biliary distension disease and the meridian flow theory;To study and analyze the differences and characteristics of postoperative pathological type distribution of biliary distension diseases at different time periods(main circulation,main qi,etc.),and to explore the possible relationship between the onset time of biliary distension diseases and their postoperative pathological type distribution;At the same time,we analyzed whether the infection indicators(leukocyte count,absolute value of neutrophils,absolute value of lymphocytes,C-reactive protein,procalcitonin,interleukin-6)of biliary distension disease at different time periods have differences and their differences,To explore the possible relationship between the onset time of biliary distension disease and its infection indicators.Provide reference and guidance for the prevention and clinical intervention of biliary distension diseases based on the concept of time medicine in traditional Chinese medicine.Methods: There are differences in the incidence and distribution of 746 patients with biliary distension during different main transportation periods.It can be seen that soil transportation(6.17-8.30)has the highest incidence,fire transportation(4.4-6.16)takes the second place,and water transportation(11.12-1.20 the next year)has the lowest incidence.The distribution of the incidence of 746 patients with biliary distension during different periods of dominant qi has differences.When Shaoyang is associated with fire(5.12-7.23),the number of cases is the highest,followed by Taiyin humid soil(7.23-9.23),Jueyin Fengmu(1.20-3.21),and Shaoyin Junhuo(3.21-5.21),while the number of cases of solar cold water(11.22-1.20 the following year)is the lowest.There was no difference in the distribution of the onset of biliary distension among 746 patients with different solar terms.The difference in the distribution of the onset time of 347 patients with biliary distension was statistically significant,with the onset peak period being from 23:00-1:00 and the relative peak period from Shenshi to Yinshi(15:00-5:00).The distribution of onset time in different main vessels in 370 patients with postoperative biliary distension of different pathological types was not statistically significant by Chi square test.The distribution of pathological types in different main qi of 370 patients with biliary distension was statistically significant through chi-square test.Acute simple cholecystitis occurred in Shaoyang Xianghuo(5.12-7.23)with the highest number of cases,while the cases of Taiyang Cold Water(11.22-1.20 the following year)with the lowest number of cases;The onset time of acute suppurative and gangrenous cholecystitis is the most in cases of Jueyin Fengmu(1.20-3.21),while the cases of Shaoyin Junhuo(3.21-5.21)are the least.There was a statistically significant difference between the leukocyte count and the absolute value of neutrophils in patients with biliary distension at the onset of the disease at different main transit times.There were statistically significant differences in leukocyte count and C-reactive protein in patients with biliary distension at different main qi periods.There was no statistically significant difference in C-reactive protein,leukocyte count,absolute neutrophil count,absolute lymphocyte count,procalcitonin,and interleukin-6 levels among patients with different solar terms and biliary distension at the onset of the disease.Results: There are differences in the incidence and distribution of 746 patients with biliary distension during different main transportation periods.It can be seen that soil transportation(6.17-8.30)has the highest incidence,fire transportation(4.4-6.16)takes the second place,and water transportation(11.12-1.20 the next year)has the lowest incidence.The distribution of the incidence of 746 patients with biliary distension during different periods of dominant qi has differences.When Shaoyang is associated with fire(5.12-7.23),the number of cases is the highest,followed by Taiyin humid soil(7.23-9.23),Jueyin Fengmu(1.20-3.21),and Shaoyin Junhuo(3.21-5.21),while the number of cases of solar cold water(11.22-1.20 the following year)is the lowest.There was no difference in the distribution of the onset of biliary distension among 746 patients with different solar terms.The difference in the distribution of the onset time of 347 patients with biliary distension was statistically significant,with the onset peak period being from 23:00-1:00 and the relative peak period from Shenshi to Yinshi(15:00-5:00).The distribution of onset time in different main vessels in 370 patients with postoperative biliary distension of different pathological types was not statistically significant by Chi square test.The distribution of pathological types in different main qi of 370 patients with biliary distension was statistically significant through chi-square test.Acute simple cholecystitis occurred in Shaoyang Xianghuo(5.12-7.23)with the highest number of cases,while the cases of Taiyang Cold Water(11.22-1.20 the following year)with the lowest number of cases;The onset time of acute suppurative and gangrenous cholecystitis is the most in cases of Jueyin Fengmu(1.20-3.21),while the cases of Shaoyin Junhuo(3.21-5.21)are the least.There was a statistically significant difference between the leukocyte count and the absolute value of neutrophils in patients with biliary distension at the onset of the disease at different main transit times.There were statistically significant differences in leukocyte count and C-reactive protein in patients with biliary distension at different main qi periods.There was no statistically significant difference in C-reactive protein,leukocyte count,absolute neutrophil count,absolute lymphocyte count,procalcitonin,and interleukin-6levels among patients with different solar terms and biliary distension at the onset of the disease.Conclusion: The onset time of biliary distension disease has a certain rule according to the analysis of main movement and main qi.The incidence rate is relatively high when the main movement is soil movement(6.17-8.30)and the main qi is Shaoyang phase fire(5.12-7.23);According to the analysis of time,patients with biliary distension have a relatively high incidence during the sub hour(23:00-1:00).There are relatively more cases of acute simple cholecystitis when Shaoyang Xianghuo(5.12-7.23)occurs,and there are relatively more cases of acute suppurative and gangrenous cholecystitis when Jueyin Fengmu(1.20-3.21)occurs;There was a statistically significant difference in the leukocyte count and the absolute value of neutrophils during different main qi periods.The leukocyte count and the absolute value of neutrophils were relatively high when the main qi was wood(1.20-4.3),while the leukocyte count and C-reactive protein values during different main qi periods were statistically significant.The leukocyte count and C-reactive protein values were relatively high when the main qi was jueyin fengmu(1.20-3.21).