Analysis Of Spousal Helicobacter Pylori Infection And Risk Factors Of Transmission

Objective:To investigate the status of H.pylori infection in spouses of patients with H.pylori infection,analyze and discuss the risk factors of spousal transmission.Methods:Patients and their spouses who completed urea breath test(¹³C-UBT or ¹⁴C-UBT)in inpatient or outpatient department of Gastroenterology,People’s Hospital of Xin Jiang Uygur Autonomous Region from November 2021 to June 2022 were selected.According to the H.pylori infection status of the subjects,the positive spouses were included in the H.pylori positive spouses group and the negative spouses were included in the H.pylori negative spouses group for comparison between groups;The subjects were given questionnaires,which included（1）personal information of the patients;（2）Social and economic conditions;（3）Living habits;（4）Family habits;（5）Questionnaires were collected.If the difference between the groups was statistically significant,the subjects were grouped into a new group,and the subjects with negative H.pylori of both spouses were included into the negative H.pylori group of the patient’s spouse（all negative group）.The positive H.pylori of one partner was included in the positive H.pylori group of the patient or spouse（single positive group）,and the positive H.pylori of both spouses were included in the positive H.pylori group of the patient’s spouse（all positive group）,and the questionnaire contents were statistically analyzed.Results:There were 53 H.pylori positive patients and 13 negative patients.The H.pylori infection of the two groups of subjects was statistically analyzed.The infection rate was 79.25%（42/53）in the H.Pylori positive partner group and 38.46%（5/13）in the H.Pylori negative partner group.The infection rate of H.pylori among spouses was significantly higher than that of the general healthy population（54.76%）.Univariate logistics analysis of the two groups showed that positive patients were risk factors for spousal H.pylori infection（P=0.01,OR=6.109）.Collect questionnaires,regroup the three groups,and then compare between groups.In general,patients’BMI（P=0.034）,marriage years（P=0.000）;In socioeconomic conditions,education level（P=0.003）,family resident population（P=0.000<0.003）;Drinking tea（P=0.019）,sharing tableware（P=0.000）,sharing toothbrush（P=0.028）,kissing times per week（P=0.007）;In other contents,periodontal disease（P=0.040）and H.pylori awareness（P=0.034）were significantly different between groups.Statistical analysis was performed on the factors that had significant differences between the groups,such as sharing tableware（single positive group:P=0.047,OR=4.173;all positive group:P=0.001,OR=17.684）,years of marriage（P=0.045,OR=4.564）,periodontal disease（P=0.032,OR=16.463）in all positive group were risk factors for spouse infection.Conclusion:1.The risk of H.Pylori positive spouses was higher than that of negative spouses.2.Patients’BMI,marriage years,socioeconomic factors,personal and family living habits and other factors play a certain role in the spousal transmission of H.pylori.3.Sharing dinnerware is a risk factor for the spread of H.pylori between spouses.4.Long marriage years and periodontal disease in all positive group were risk factors for spousal transmission of H.pylori.5.Publicity and education on H.pylori should be strengthened in the community to raise awareness of H.pylori infection and reduce the risk of spousal transmission of H.pylori infection.