Analysis Of Risk Factors Associated With Hypogonadism In Male Hyperuricemia Patients

Objective:This study mainly analyzed the composition ratio of male hyperuricemia(HUA)patients complicated with hypogonadism and the differences of various metabolic indexes between male hyperuricemia(HUA)patients complicated with hypogonadism and normal gonadism,further explored the related risk factors of male HUA patients complicated with hypogonadism,and provided clinical basis for early sex hormone screening and intervention treatment for high-risk groups.Method:General data,laboratory examination,sex hormone indexes and other clinical data of 217 male patients with HUA admitted to the Department of Endocrinology of the People’s Hospital of Xinjiang Uygur Autonomous Region from June 2021 to August 2022 were collected.According to the diagnostic criteria of male hypogonadism,98 cases of HUA patients with hypogonadism were selected as case group.119 cases of HUA patients with normal gonadal function were used as control group.The differences of different metabolic indexes between the two groups and the correlation of male hypogonadism were analyzed.Results:(1)All subjects were 40-76 years old.In the case group,the mean age was(54.02±8.72)years old,the mean body mass index(BMI)was(30.59±4.86)kg/m~2,and the average homeostasis model assessment insulin resistance index(HOMA-IR)was(3.97±1.68).Control group:40 to 71 years old,average age was(53.13±6.14)years old,average BMI was(25.38±3.87)kg/m~2,average HOMA-IR was(2.79±1.94).(2)Among 217hospitalized patients,45.16%were male patients with HUA complicated with hypogonadism.(3)The levels of waist circumference(WC),BMI,diabetes course,fasting blood glucose(FPG),fasting insulin(FINS),HOMA-IR,alanine aminotransferase(ALT),serum uric acid(SUA)and sex hormone binding globulin(SHBG)were significantly increased in hypogonadism group compared with normal gonadism group.The levels ofγ-glutamyltransferase(GGT),red blood cell count(RBC),hemoglobin(HB),25-hydroxyvitaminD[25(OH)D],progesterone(P),estradiol(E2),dehydroepiandrosterone(DHEA)and serum free triiodothyronine(FT3)were significantly decreased(P<0.05).(4)Compared with the normal gonadal group,the proportions of hypogonadism combined with obesity(OB),non-alcoholic fatty liver(NAFLD),hyperlipidemia(HLP),hypertension(HBP),coronary heart disease(CHD),angiotensin receptor antagonist(ARB)and aspirin were significantly increased(P<0.05).(5)Correlation analysis showed that free testosterone(FT)was negatively correlated with WC,BMI,FPG,FINS,HOMA-IR,SUA,SHBG and ALT,and positively correlated with25(OH)D,RBC,P,E2,DHEA and FT3(P<0.05).(6)logistic regression analysis(step-backward method)showed that SUA,diabetes duration,BMI,HOMA-IR,ALT,25(OH)D and hypertension were all risk factors for male patients with HUA combined with hypogonadism(P<0.05).Conclusions:Male patients with HUA are often complicated with hypogonadism,among which SUA,diabetes course,BMI,HOMA-IR,ALT,25(OH)D and hypertension are all risk factors for male hypogonadism.