Analysis Of Clinical Characteristics And Warning Indicators Of Acute Kidney Injury In Heat Stroke

Objective: The clinical characteristics of Acute Kidney Injury(AKI)caused by Heat Stroke(HS)were analyzed retrospectively,and the clinical warning indicators were discussed.Method: A retrospective study was conducted to select all the data that met the exclusion requirements and were clearly diagnosed in the General Hospital of Xinjiang Military Region from July 1,2015 to July 1,2022,and based on the standardized test results of heat emission disease and the opinions of treatment experts,In addition,according to KDIGO’s standard,the two groups were divided into HS group with concurrent AKI(n=108)and HS group without concurrent AKI(n=38),and the differences between the two groups were compared.Univariate and multivariate Logistic regression analysis was used to identify warning indicators for comorbid AKI due to HS.Results:(1)Of the 146 cases of patients treated with thermal radiation,108 cases were complicated with AKI,and HS complicated with AKI made up 74% of the cases.(2)There were significant differences in sex,urine volume,body temperature,cyys C(CysC),neutrophils,urea,uric acid,creatinine,e GFR,and leukocyte levels in all of the groups with AKI(P < 0.05)and these differences were not statistically significant.(3)Using regression analysis using Single Logistic,body temperature,Serum CysC,blood urea,blood uric acid,e GFR,urine volume,and Serum Creatinine(Scr)were found to be significant for complicated HS with AKI,with a level of statistical significance(P<0.05).Multivariate Logistic regression analysis showed that uric acid level,body temperature and serum CysC level had some significance in the case of complicated HS with AKI.(4)ROC curve analysis showed that parameters independent of body temperature,Scr,and serum CysC levels all had some early warning value for the occurrence of patients with HS complicated by AKI.The area under the ROC curve of the serum CysC value was0.679 ～ 0.855 95% confidence interval,P < 0.001,and the value of the AUC was 0.767.2The results of the present study were similar to those of previous studies.The sensitivity and specificity of serum CYSC for the diagnosis of AKI were 0.684 and 0.843 respectively.For body temperature,the area under the ROC curve was(95% confidence interval 0.655～ 0.867,P < 0.001),the value of the AUC was 0.761,and the sensitivity and specificity for the diagnosis of HS complicated by AKI were 0.605 and 0.926,respectively.2 The results of this study were similar to those of previous studies.3 The results of the present study are presented in Table 1.The area under the ROC curve for blood uric acid concentration was(95% confidence interval 0.606-0.782,P < 0.001),the AUC was 0.694,and the sensitivity and specificity for the diagnosis of HS complicated by AKI were 0.711 and 0.648,respectively.6 The results of this study are presented in Table 1.3 The results of the present study are shown in Table 1.(5)The AUC value for serum CysC in combination with body temperature and blood uric acid level was 0.867.2 The results of this study are presented in Table 1,the 95% confidence interval was 0.862 ～ 0.932,and the sensitivity and specificity were 0.658 and 0.91,respectively.Conclusions:(1)Higher ambient temperature(37℃-40℃)was associated with increased incidence of HS and AKI.(2)ROC curve showed that blood uric acid,body temperature and serum CysC were more effective in clinical evaluation of patients with HS and AKI,and the combined detection has good sensitivity and specificity.