Vitamin D Levels And Their Association With Osteoporosis In Patients With Chronic Liver Disease

Objective:To investigate the relationship between serum vitamin D level and bone mineral density in patients with chronic liver disease.Methods:A total of 213 patients with chronic liver disease from January 2021 to August 2022 to the Infectious Liver Disease Center of the First Affiliated Hospital of Xinjiang Medical University were taken as the research subjects,and their basic data,disease severity,vitamin D and bone density related data were collected,and the serum vitamin D level and its relationship with age,gender and disease severity in patients with chronic liver disease were retrospectively analyzed,and the distribution of bone density degree and the factors affecting bone density degree of chronic liver disease were analyzed.Results:Among the 213 patients with chronic liver disease,83(39%)had vitamin D deficiency,92(43.2%)had vitamin D deficiency,and only 38(17.8%)had normal vitamin D.The vitamin D level in men(50.29±35.23)was significantly higher than that in women(34.03±14.00),and the vitamin D level in patients over 50 years old gradually decreased with age.The vitamin D level(44.05±27.79)of 130 patients with non-cirrhosis of 213 patients with chronic liver disease was higher than that of 83 patients with cirrhosis(34.60±21.04).Of the 213 patients with chronic liver disease,116(54.5%)had normal bone density,79(37%)had low bone mass,and 18(8.5%)had osteoporosis.There was a significant difference in bone density between the 40-49 years old and the50-59 years old,and there was a significant difference between the groups when the vitamin D level was 30 nmol/L.There were differences between groups between patients with non-cirrhosis and bone mineral density in patients with cirrhosis,and there were also differences in bone density between the two groups after patients with cirrhosis were divided into compensated group and decompensated group.Conclusion: Vitamin D insufficiency or deficiency is common in patients with chronic liver disease,and the average vitamin D level in women is lower than that in men,and women are more likely to have vitamin D deficiency or deficiency.Vitamin D levels decline with age in patients older than50 years.Gender and disease severity are risk factors for vitamin D insufficiency and deficiency in patients with chronic liver disease.Patients with chronic liver disease often have osteoporosis and even osteoporosis.There was a significant difference in bone density between the 40-49 years old and the 50-59 years old,indicating that patients over 50 years old were more likely to have osteoporosis and osteoporosis.After 83 patients with cirrhosis were divided into compensated group and decompensated group,it was found that the degree of bone density between the two groups also differed,suggesting that patients with cirrhosis,especially those in the decompensated stage of cirrhosis,were more likely to have low bone mass or even osteoporosis.The degree of bone mineral density was significantly different between groups when vitamin D levels were grouped into 30 nmol/L.