Impacts Of Triglyceride-Glucose Index On Prognosis Of Patients With Acute Coronary Syndrome And Metabolic Syndrome

Objective: Aim The prognostic value of the triglyceride-glucose index in patients with an acute coronary syndrome and the metabolic syndrome is uncertain.Method A prospective cohort study was conducted in the First Affiliated Hospital of Xinjiang Medical University.A total of 453 patients with ACS and MS were enrolled.The baseline data of patients at admission were collected,including basic information,medication,surgical data and other clinical characteristics.Follow-up was conducted by telephone and medical records.The primary endpoints included all-cause death,rehospitalization for angina and repeat revascularization.The best cut-off value of Ty G index was used to group the patients,and the baseline characteristics between the two groups were compared.The Kaplan-Meier survival curve of the two groups of patients with endpoint events was drawn,and the differences between the two groups were compared by log-rank test.Multivariate COX regression analysis was used to analyze the predictive value of Ty G index for the poor prognosis of ACS patients with MS.Restricted cubic splines were plotted to show the relationship between Ty G index and primary endpoint events.Result The Ty G index in the group with primary endpoint events was significantly higher than that in the group without primary endpoint events(P < 0.001).Multivariate COX proportional hazards analysis showed that when Ty G index was used as a categorical variable,the risk of primary endpoint events in the high Ty G index group was 1.822 times that in the low Ty G index group(HR 1.822,95%CI1.243-2.669,P=0.002).As a continuous variable,Ty G index was still an independent predictor of primary endpoint events(HR 1.671,95%CI 1.329-2.100,P < 0.001).Conclusion Triglyceride-glucose index is an important predictor of poor prognosis in acute coronary syndrome patients with metabolic syndrome.