Analysis Of Changes In Macular Blood Flow Density And Morphological Structure After Conbercept Combined With Subthreshold Laser Treatment Of Diabetic Macular Edema Based On OCTA

Objective:To observe the changes of macular blood flow density and macular morphological structure after conbercept combined with subthreshold laser treatment of diabetic macular edema（DME）.Methods:A total of 60 cases and 60 eyes of DME patients diagnosed in the First Affiliated Hospital of Bengbu Medical College from April 2021 to April2022 were randomly divided into two groups:control group and observation group（30 cases in each group）,and the observation group was given Intravitreal injection of Conbercept combined with retinal subthreshold laser treatment,intravitreal injection of Conbercept on the second day after subthreshold laser treatment,Conbercept was injected once a month for 3consecutive months,and the control group was given The patients were treated with intravitreal injection of Conbercept,and the injection frequency and interval were the same as those of the observation group.In addition to the changes of blood flow density of superficial macular capillaries（SCP）and deep macular capillaries（DCP）before and after treatment,the changes of central macular retinal thickness（CMT）and best corrected visual acuity（BCVA）were also analyzed.Result:1.SCP:Before and after treatment,there was no significant difference in SCP blood flow density between the two groups(F _group=0.026,P _group=0.994,F _time=0.034,P _time=0.967).2.DCP:There were significant differences in DCP blood flow density between the two groups and at different time points before and after treatment（P<0.01）,that is,DCP blood density increased with time at 1mo,2mo and 3mo in both groups（P<0.05）,but the increase rate of observation group was higher than control group（P<0.05）.3.CMT:There were significant differences in CMT between the two groups and at different time points(F _group=124.132,P _group=0.000,F _time=8.512,P _time=0.000).That is,CMT of the two groups showed a decreasing trend with the passage of time at 1mo,2mo and 3mo after surgery（P<0.01）,and the reduction rate of observation group was higher than control group（P<0.01）.4.BCVA:Before and after treatment,BCVA was significantly different between the two groups(F _group=89.736,P _group=0.000,F _time=21.133,P _time=0.000).The postoperative BCVA of 1mo,2mo and 3mo in both groups was significantly higher than that before surgery,and the postoperative BCVA of 2 and 3mo was significantly higher than that of 1mo,the difference was statistically significant.BCVA was significantly improved in 1mo,2mo and 3mo observation groups compared with control group（P<0.05）.Conclusion:1.Intravitreal injection of Conbercept can reduce retinal thickness in macular area and improve visual acuity in patients with DME.2.Conbercept combined with laser photocoagulation under early threshold can reduce retinal thickness in macular area,reduce macular edema and improve visual acuity in DME patients in a short term,with fewer complications,so it is a safe and effective treatment.3.Intravitreal injection of Conbercept can improve the blood flow density of deep vessels and improve visual function.However,laser treatment of DME with Conbercept combined with threshold is more effective in the short term.