How Lactobacillus Rhamnosus Affects Intestinal Microecology And Clinical Efficacy In Children With Bronchial Asthma

Objective: To investigate whether Lactobacillus rhamnosus can effectively assist in the treatment of bronchial asthma in children with bronchial asthma by comparing the abundance of gut microbiota,cytokines,lung function,and clinical control levels between the standard treatment group and the LGG adjuvant treatment group.Method: Clinical data and fecal samples of children with bronchial asthma who met the inclusion criteria at the Pediatric Center of the First Affiliated Hospital of Xinjiang Medical University from December 2021 to December 2022 were collected.They were divided into a standard treatment group and an LGG adjuvant treatment group according to the wishes of their families.The intervention treatment lasted for 3 months,and the impact of Lactobacillus rhamnosus adjuvant treatment on the intestinal microbiota and clinical efficacy of children with bronchial asthma was analyzed.Result: 1)This study analyzed the composition of gut microbiota in 93 children with bronchial asthma.At the phylum level,there were 4dominant bacterial phyla,namely Bacteroidetes,Actinobacteria,Proteobacteria,and Fusobacteria;At the genus level,there are 11 dominant bacteria genera,including Bacteroides,Bifidobacterium,Fecal Bacillus,Procellus,Eubacterium,Ruminococcus,Escherichia,Bacteroides,Spirillum,Fusobacterium and Clostridium.2)Further analysis of the abundance of gut microbiota in the two groups of children after treatment showed that adjuvant therapy with Lactobacillus rhamnosus significantly increased the abundance of gut microbiota in the children,with Bifidobacterium possibly being an important genus causing differences between the two groups.3)After treatment,the eosinophil count of both patients decreased with statistical significance(P<0.05);After treatment,the total serum Ig E decreased compared to before treatment,but the difference was not statistically significant(P>0.05).After treatment,the eosinophil levels in the LGG adjuvant treatment group were significantly lower than those in the standard treatment group.4)IFN after treatment in two groups of patients in this study-γ The levels have increased compared to before,and the IL-2 levels have decreased compared to before,with a statistically significant difference(P<0.05).Adjuvant therapy with Lactobacillus rhamnosus has an effect on IFN-γ、 The impact of IL-2 levels is more significant.The difference in IL-6in this experiment was statistically significant in the standard treatment group,but there was no significant difference before and after treatment in the LGG adjuvant treatment group(P>0.05).5)This study found that all indicators of lung function in the two groups of children improved compared to before,but there was no statistical difference(P>0.05).6)After treatment,the number of uncontrolled asthma patients in the standard treatment group(26),partially controlled asthma patients(18),and completely controlled asthma patients(12);The LGG adjuvant treatment group had an uncontrolled population of 7,partially controlled population of 17,and fully controlled population of 13.The control level of Lactobacillus rhamnosus adjuvant treatment was better than that of the standard treatment group,and the difference was statistically significant(P<0.05).Conclusion: 1)The abundance and distribution uniformity of gut microbiota in patients with bronchial asthma have undergone significant changes.The number of lactobacilli and bifidobacteria significantly decreased.2)Adjuvant therapy with Lactobacillus rhamnosus can significantly increase the abundance of intestinal microbiota in children with bronchial asthma,possibly by improving the clinical control level of asthma,reducing eosinophil count,and regulating cytokine balance.