Research On The Correlation And Diagnostic Value Of T Lymphocyte And Inflammatory Cytokines In Peripheral Blood To Ovarian Endometriosis

Objective:To explore the correlation and diagnostic value of T lymphocyte,inflammatory cytokines in peripheral blood to ovarian endometriosis(OMs).Methods:From October 2020 to June 2022,72 patients with pathologically confirmed EMs undergoing open or laparoscopic surgery were admitted to the case group,37 patients were divided into stage Ⅰ-Ⅱ and there were 35 patients in stage Ⅲ-Ⅳ.72 patients with Simple cyst or benign teratomas after the same period of surgery were selected as control group.Flow cytometry was used to detect T lymphocyte,inflammatory cytokines in peripheral blood and gather related clinical data to discuss the influencing factors of OMs.Patients in stage of Ⅰ-Ⅱ and II-IV in OMs were further compared with CD4~+,CD8~+and TNF-αwhich are independent influencing in the peripheral blood indexes express differences.Evaluating the diagnostic efficacy of OMs by three indicators,both individually and in combination.Results:(1)CD8~+,IL-2,IL6,IL-10,TNF-α,menarche age<13 years,menstrual period days>6 days,dysmenorrhea,abortion surgery or cervical surgery history and caesarean section history are OMs risk factors,CD4~+and CD4~+/CD8~+are OMs protection factors.(2)CD8~+,TNF-α,menstrual period>6 days,dysmenorrhea,abortion surgery or hysteresis surgery and uterine surgery history are independent risk factors for OMs,and CD4~+is an independent protective factor for OMs.(3)Significant differences between stage Ⅰ-Ⅱ and Ⅲ-Ⅳ of OMs in CD4~+,CD8~+and TNF-α(P<0.05).(4)The combined detection of CD4~+,CD8~+and TNF-αcan improve the diagnostic efficiency of OMs.Conclusion:T lymphocyte subsets and inflammatory cytokines Peripheral blood play a role in the occurrence of OMs,CD4~+,CD8~+and TNF-αare involved in disease progression and the combined detection of the three may have high application value in the diagnosis of OMs.