Predictive Effect Of Triglyceride-Glucose Index On Adverse Prognostic Events In Patients With Type 2 Diabetes Mellitus And Ischemic Cardiomyopathy

Objective:Triglyceride-glucose(Ty G)index is regarded as an independent predictor of cardiovascular diseases(CVD)consequences and a reliable surrogate measure of insulin resistance.The Ty G index’s predictive significance in patients with type 2 diabetes mellitus(T2DM)and ischemic cardiomyopathy(ICM),however,is still unclear.The aim of this study is to investigate the relationship between Ty G index and Major adverse cardiac and cerebral events(MACCE)in ICM patients with T2 DM.Methods: In this investigation,1,514 consecutive individuals with ICM and T2 DM were included.The tertile of the Ty G index values was used to categorize these patients into three groups,MACCEs were also noted.[fasting triglycerides(mg/d L)× fasting plasma glucose(mg/d L)/2] equation was employed to obtain the Ty G index.Results: After age,BMI and other potential confounders were corrected,the scores of multivariate COX regression models for chest pain [9.056(4.370 to 18.767),p<0.001],acute myocardial infarction[4.437(1.420 to 13.869),p=0.010],heart failure [7.334(3.424 to 15.708),p<0.001],cardiogenic shock [3.707(1.207 to 11.384),p=0.022],malignant arrhythmia [5.309(2.367 to 11.908),p<0.001],cerebral infarction [3.127(1.596 to 6.128),p<0.001],gastrointestinal bleeding[4.326(1.612 to 11.613),p=0.004],all-cause death [4.502(3.478 to 5.827),p<0.001] and cumulative incidence of MACCEs [4.856(3.842 to 6.136),p<0.001]increased significantly with a rise in Ty G index levels(all p<0.05).The time-dependent ROC analysis indicated that the area under the Ty G index curve(AUC)reached 0.653 in the 3rd year,0.688 in the 5th year,and 0.764 in the 10 th year.Subsequent to the incorporation of the Ty G index into the base risk model,enhanced predictive effectiveness of this model on MACCEs can also be observed NRI: 0.361(0.253-0.454);C-index:0.678(0.658-0.698);IDI:0.138(0.098-0.175);(all p<0.05).Conclusion: A noteworthy correlation between Ty G index and the occurrence of MACCEs in patients with ICM and T2 DM was observed in this study.The results of this study imply that the Ty G index could be beneficial in evaluating the probability of MACCEs and for initiating preventive action in people who have both ICM and T2 DM.