Correlation Analysis Between SII,CAR And The Degree Of Coronary Lesions In Elderly AMI And The Occurrence Of MACE In Hospital

Objective: To investigate the correlation between systemic immune inflammation index(SII)and C-reactive protein/albumin ratio(CAR)and the severity of coronary artery lesions and major adverse cardiovascular events(MACE)during hospitalization in elderly patients with acute myocardial infarction(AMI).Method: A retrospective study of 198 AMI patients aged ≥ 60 who visited the First Affiliated Hospital of Xinjiang Medical University from June 2019 to June 2022 were included as the study subjects,and 100 patients with non-coronary heart disease who visited the same period were selected as the control group.General data and laboratory data such as blood routine,blood biochemistry,and inflammatory indicators were collected to compare the differences between groups.According to the results of coronary angiography,AMI patients were divided into single and double vessel lesion groups,three branches and/or left main lesion group,and at the same time,according to whether MACE occurred in the hospital,they were divided into MACE group and non-MACE group,and the correlation between SII and CAR and the degree of coronary lesion and MACE in elderly AMI patients was analyzed,and the predictive value was evaluated through ROC curve.Results: The SII and CAR of the AMI group were higher than those in the control group,and the differences were statistically significant(P< 0.05).SII,CAR and Gensini scores were positively correlated(r=0.303,0.167,P<0.05),which were independent risk factors for the occurrence of three and/or left main trunk lesions in coronary arteries and the occurrence of MACE in hospital(P< 0.05).Through ROC curve analysis,the area under the curve of the three and/or left main trunk lesions of the coronary artery in elderly AMI patients was 0.764,and the area under the curve of the joint prediction of MACE in hospital was 0.802,both of which were better than the single index.Conclusion: Elevated SII and CAR are associated with the degree of coronary artery lesions and adverse prognosis in hospitals in elderly AMI patients.In clinical practice,it can be used as a potential application index to assist clinicians to judge the condition and evaluate the prognosis,and provide a reference for risk stratification in elderly AMI patients.