The Correlation Between ANXA6 Gene Polymorphism And The Level Of Aspartate Transaminase In College Students

Objective: Objective To clarify the correlation between single nucleotide polymorphism at the ANXA6 gene SNP1(rs2303022)locus and glutathione aminotransferase(AST)levels in a university student population and to explore the effect of polymorphism at this gene locus on dyslipidemia.Methods: We collected 7095 students who participated in the physical examination of students in Xinjiang Medical University from October to November 2018.Using the research strategy of extreme phenotypes,we ranked the measured levels of low density lipoprotein cholesterol from small to large.We took two extremely low and extremely high samples,a total of 1032 research subjects,and conducted a questionnaire survey of general health information and routine liver and kidney function,fasting blood glucose,blood lipids,and other tests,and took blood samples,Further DNA extraction,genotyping with SNPscan genotyping technology,and analysis of collected data.Results: The genotype of ANXA6 gene rs2303022 was significantly different in male patients with recessive model(CC+CG;GG)(P<0.05).The genotype of ANXA6 gene rs2303022 was significantly different in three cases of dominant model(CC;CG+GG),recessive model(CC+CG;GG)and allele(C;G)(P<0.05).After excluding the confounding factors by non-conditional multivariate logistic regression analysis.It can be found that the increase of high-density lipoprotein is a risk factor for the increase of glutamic-oxaloacetic transaminase(OR=2.11,P=0.04,95% CI: 1.05 ± 4.27).Conclusion: The level of glutamic-oxaloacetic transaminase in male college students with the GG genotype at SNP1 of ANXA6 gene is higher.In the Han ethnic group college students,the ANXA6 gene SNP1(rs2303022)genotype significantly increased the level of glutamic-oxaloacetic transaminase in the college students with CC genotype,GG genotype and C or G gene compared with other gene populations.The elevated level of high-density lipoprotein cholesterol in college students will increase the risk of elevated glutathione aminotransferase level.This study provides a potential theoretical basis for gene diagnosis,treatment,and early intervention of cardiovascular and cerebrovascular diseases.