The Value Of Systemic Immune-Inflammation Index(SII) Combined With Prognostic Nutritional Index(PNI) In Judging The Prognosis Of Gastric Cancer

Objective To investigate the relationship between pre-treatment systemic immuneinflammation index(SII),prognostic nutritional index(PNI)and the clinicopathological characteristics and prognosis of gastric cancer patients,and further discuss the prognostic significance of COSII-PNI.Methods The Clinical data of 240 patients with gastric cancer who underwent surgical treatment in our hospital from 2014 to 2017 were collected retrospectively and regularly followed up,To construct inflammatory related index SII and nutritional immune index PNI,Plotting ROC curves to determine the best cut-off values for SII,PNI prediction prognosis,Chi-square test analyzed the relationship between SII,PNI and clinicopathological characteristics of gastric cancer,Spearman rank correlation is used to analyze the correlation between variables,Kaplan-Meier survival curve,Cox proportional risk regression model for estimating the prognostic value of SII and PNI.Results SII was associated with age,tumor size,location,gross type,depth of infiltration,lymph node metastasis,p TNM stage,and presence of anemia(P<0.05),PNI values correlated with tumor size,depth of infiltration,lymph node metastasis,p TNM stage,degree of differentiation,and whether anemia was present(P<0.05),PNI was significantly and negatively correlated with SII(r =-0.556,P<0.001),The 5-year overall survival rates of patients in the low SII and high PNI group were higher than those in the high SII and low PNI groups,respectively(P<0.001).Multivariate analysis showed that SII,depth of invasion,lymph node metastasis,p TNM stage,degree of differentiation and whether adjuvant chemotherapy was administered were independent risk factors for prognosis(P<0.05),As a new scoring system,COSII-PNI achieved good prognostic stratification(P<0.05),especially for stage III gastric cancer patients.Conclusion High SII and low PNI values may be strong indicators of aggressive biological behavior and poor prognosis of gastric cancer,The novel scoring system COSII-PNI is of great potential prognostic value.