The Clinical Observation On The Treatment Of Phlegm-stasis Paralysis Type Rheumatoid Arthritis With Anxiety State By Resolving Phlegm And Relieving Depression

Objective:The clinical efficacy and safety of the treatment of phlegm-stasis paralysis type rheumatoid arthritis with anxiety state were objectively evaluated through clinical observation of the method of resolving phlegm and relieving depression.Methods:According to the inclusion and exclusion criteria,62 patients with rheumatoid arthritis from the outpatient clinic and ward of the Department of Rheumatology,The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were collected and randomly divided into treatment and control groups,with 31 cases in each group.The control group was given Leflunomide tablets and St.John’s wort extract,while the t reatment group was given the self-prepared formula based on the control group to dissolve phlegm,pass through the ligaments and relieve depression.The treatment period was 8 weeks in both groups.Erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),Rheumatoid Factor(RF),number of joint induration,number of joint swelling,visual analogue pain scale(VAS)were observed in both groups before and after treatment.Visual Analogue Scale(VAS),Disease activing score in 28 joints(DAS28),Self-Rating Anxiety Scale(SAS),Chinese medicine syndrome score,safety indicators,and adverse reactions during treatment.The data of the patients were compiled,and the database of this trial was constructed.Results:1.Before treatment,there was no statistical difference between the two groups in terms of general information and observation indexes,which were comparable(P>0.05).2.After treatment,the clinical efficacy of the two groups was compared,the total effective rate of the control group was 75.86%,the total effective rate of the treatment group was 93.33%,the treatment group had excellent efficacy compared with the control group,P=0.046<0.05,the difference between the two groups was statistically significant.3.After treatment,the CRP,ESR,RF,number of joint pressure pain,number of joint swelling,VAS score,DAS28 score,and TCM evidence score of the cases in both groups decreased compared with those before treatment.4.After treatment,the SAS of both groups decreased,and the SAS scores before and after treatment were statistically different between the two groups(P<0.05),and there was a treatment effect in both the treatment and control groups,with a greater decrease in the treatment group than the control group,and the improvement of the anxiety state in the treatment group was better than that in the control group.5.The safety indexes were recorded before and after treatment in both groups,and no adverse reactions were produced.Conclusion:The method of resolving phlegm and relieving depression can effectively improve the clinical symptoms of patients with phlegm-stasis paralysis type RA with anxiety state,effectively alleviate the anxiety state and inhibit the inflammatory response,and is safe and effective for clinical application,which is worthy of in-depth study.