Analysis Of Professor Zhang Yang’s Medication Rules In The Treatment Of Chronic Atrophic Gastritis Based On Date Mining

Objective:Collect and sort out the outpatient case data of Professor Zhang Yang in the treatment of chronic atrophic gastritis,use the traditional Chinese medicine inheritance computing platform 3.0 to review and analyze the basic information and prescription of patients,summarize the medication rules and experience of Professor Zhang Yang in the treatment of this disease,and provide clinical reference for the treatment of atrophic gastritis with traditional Chinese medicine.Methods:From December 2021 to December 2022,the general data and prescription medication of patients with chronic atrophic gastritis who were treated in Professor Zhang Yang’s outpatient clinic were collected,and the data of 122 patients included were entered into Excel tables,standardized and unified data were imported into the traditional Chinese medicine inheritance computing platform 3.0,and the prescription database was established for statistical analysis,frequency analysis,and correlation analysis.Results:1.Basic information: 122 patients included in this study,56 male patients,66 female patients,male: female=1:1.17.The onset age is concentrated in 51-60 years old.2.Results of symptoms,syndrome types and tongue images: the top 10 symptoms with the most frequency are fullness,acid regurgitation,fatigue,bitter mouth,dry mouth,belching,hiccup,chills,constipation,and lack of food;The first two syndrome types with the largest proportion are damp-heat syndrome of spleen and stomach and spleen and stomach weakness syndrome;The first three tongue images with the highest frequency are "fat and large tongue","yellow and greasy tongue coating" and "tooth marks".3.The results of the nature,taste,meridian tropism and efficacy of medicines: among the four kinds of medicines,warm,neutral and cold medicines are used most;Among the five flavors,bitter,pungent and sweet medicines are most used;The meridians of medicines are mainly spleen,lung,stomach and liver.The efficacy categories of the medicines are mainly qi regulating medicines,tonifying medicines,blood stasis-removing medicines,heat-clearing medicines,and dietetic medicines.4.Results of medicine frequency : Among the 122 prescriptions included in this study,122 traditional Chinese medicines were used,with a cumulative frequency of 3676 times.Among them,45 traditional Chinese medicines were used more than 20 times,with a cumulative frequency of 3287 times,accounting for 89.42%.The top 15 traditional Chinese medicines with the highest frequency are: Bupleurum,Ligusticum chuanxiong,Licorice,Tangerine peel,Poria cocos,Codonopsis pilosula,Paeoniae radix alba,Fried malt,Malt,Citron,Bergamot,Aucklandiae radix,Coprinus corneum,Cyperi rhizoma,and Fructus aurantii.5.Results of medicine rules: the frequency of medicines was counted,and the basic formula of the mentor was obtained: Licorice-Ligusticum chuanxiong-Bupleurum-Tangerine peel-Poria cocos-Codonopsis pilosula-Paeoniae radix alba;The association analysis of medicines was carried out,with a support of 60% and a confidence of 0.9.3401 association rules and 1174 medicine use patterns were obtained among 19 medicines,and the four commonly used medicine combinations were displayed:Citron-Bergamot-Aucklandiae radix-Cyperi rhizoma,Malt-Fried malt-Coprinus corneum,Lobelia chinensis Lour-Scutellaria barbata-Hedyotis diffusa-Radix isatidis,and Salvia miltiorrhizae-Cyperi rhizoma.Conclusion:1.Professor Zhang Yang believes that the basic pathogenesis of chronic atrophic gastritis is qi stagnation and spleen deficiency,so the classic prescription of Chaihu Shugan Powder and Sijunzi Decoction,based on Licorice-Ligusticum chuanxiong-Bupleurum-Tangerine peel-Poria cocos-Codonopsis pilosula-Paeoniae radix alba,is intended to dredge the stagnant qi,replenish the deficiency of the central state,regulate the qi and blood,and dredge the liver and regulate the spleen;2.Professor Zhang Yang pointed out that damp-heat,blood stasis,turbid phlegm and other pathological products are also important factors that aggravate the development of the disease.Therefore,it is combined with Citron-Bergamot-Aucklandiae radix-Cyperi rhizoma for soothing the liver and regulating the qi,Malt-Fried malt-Coprinus corneum for invigorating the spleen and digesting,Lobelia chinensis Lour-Scutellaria barbata-Hedyotis diffusa-Radix isatidis for clearing away heat and toxic material,Salvia miltiorrhizae-Cyperi rhizoma for activating blood circulation and resolving stasis and other medicine combinations;3.Professor Zhang Yang’s experience in treating chronic atrophic gastritis is as follows: soothing the liver to relieve depression,regulating qi and promoting stagnation;Activating blood circulation to remove blood stasis and harmonizing qi and blood;Clearing away heat and dampness,eliminating phlegm and dispersing nodules;Strengthen the spleen and regulate the stomach,replenish qi and nourish yin;China and the West are integrated and complement each other.