The Relationship Between Childhood Trauma And Serum BDNF Level And Related Factors In Patients With Schizophrenia

Objective:The purpose of this study was to explore the incidence of childhood trauma in patients with schizophrenia and its relationship with clinical psychiatric symptoms and cognitive function,and to further explore the relationship between childhood trauma and serum brain-derived neurotrophic factor(BDNF)level.Method:In this study,127 patients with schizophrenia who met the inclusion and exclusion criteria were enrolled in Chaohu Hospital Affiliated to Anhui Medical University from November 2021 to August 2022.Their general socio-demographic data were collected,the Positive and Negative Syndrome Scale(PANSS),the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),and the Childhood Trauma Questionnaire Short Form(CTQ-SF)were assessed,and blood was collected to measure serum BDNF levels and inflammatory cytokines.After data collection and collation,all the samples were divided into childhood trauma group and non-childhood trauma group according to the scoring criteria of childhood abuse questionnaire,and the data were statistically analyzed.Results:1.There are 103 schizophrenic patients in this study had experienced at least one kind of childhood trauma,that is,the incidence of childhood trauma was 81.1%,and the incidence of emotional neglect was the highest.2.There were significant differences in gender(χ~2=4.07,P=0.04)and marital status(χ~2=3.47,P=0.05)between the childhood trauma group and the non-childhood trauma group.3.The negative symptom score in the childhood trauma group was higher than that in the non-childhood trauma group(t=3.20,P=0.002).Negative symptoms were associated with physical neglect(t=2.95,P=0.004)and emotional neglect(t=3.67,P<0.001)was statistically significant.4.Scores of each factor of RBANS in the childhood trauma group were lower than those in the non-childhood trauma group,but were not statistically significant.5.The serum BDNF level and inflammatory factors in the non-childhood trauma group were lower than those in the childhood trauma group,and the serum TNF-αlevel was significantly different between the two groups(t=0.91,P=0.010).6.Correlation analysis showed that childhood trauma was positively correlated with gender(r=0.179,P=0.044),negatively correlated with negative symptom(r=-0.276,P=0.002),and negatively correlated with serum TNF-αlevel(r=-0.227,P=0.010).The negative symptom was negatively correlated with physical neglect(r=-0.255,P=0.004)and emotional neglect(r=-0.312,P<0.001).Emotional neglect was negatively correlated with the total score of PANSS(r=-0.174,P=0.050).7.Multiple linear regression analysis showed that childhood trauma had a statistically significant effect on negative symptom(β=-0.177,P=0.036).Emotional neglect was statistically significant for negative symptom(β=-0.214,P=0.012).Serum TGF-βlevel(β=-0.184,P=0.020)had significant differences on attention.Conclusion:Through scale evaluation and hematological index measurement,this study found that schizophrenia patients who experienced childhood trauma had more severe clinical symptoms and more obvious cognitive decline.Among them,physical neglect and emotional neglect were very important for the clinical psychiatric symptoms of schizophrenia patients,especially the negative symptoms.The effect of childhood trauma on serum BDNF level has not been found,but serum TNF-αlevel is negatively correlated with childhood trauma,and the serum TGF-βlevel may have a certain predictive effect on cognitive decline.