Prediction Of Severity Of Common Femoral Artery Intima Thickness And Hypersensitivity CRP And Hcy In Patients With Hypertension And OSAHs

Objective: To investigate the significance and application of common femoral artery intimamedia thickness,hypersensitive C-reactive protein(Hs-CRP)and Hcy levels in patients with hypertension complicated with obstructive sleep apnea and hypopnea syndrome(OSAHS).Methods:A total of 85 hypertensive patients,including 51 males and 34 females,who were hospitalized for continuous treatment from December 2021 to December 2022,were collected.All patients underwent polysomnosis monitoring and were divided into hypertension combined with moderate and severe OSAHS group(group A,n=34),hypertension combined with mild OSAHS group(group B,n=23)and simple blood pressure group(group C,n=28)according to AHI index.General data of patients were collected.Serum hs-CRP,Hcy and femoral artery intimedia thickness were measured on the same day or the next morning.Femoral intima thickness,hypersensitive CRP,Hcy and sleep-related indexes were compared between the three groups.Results: There were significant differences in the levels of Hcy and hypersensitive CRP among the three groups(P < 0.05).Compared with group C,the levels of Hcy and hypersensitive CRP in groups A and B were significantly increased,with statistical significance(P < 0.05).Compared with group C,intima-media thickness of common femoral artery in groups A and B was increased,and more significantly in group A,with statistical significance(P < 0.05).Correlation analysis showed that serum Hcy and Hs-CRP levels and femoral intima media thickness were positively correlated with AHI and oxygen reduction index(ODI)(r > 0,P < 0.05),but negatively correlated with minimum oxygen saturation(r < 0,P < 0.05).Conclusion:The thickness of femoral intima media,hypersensitive CRP and Hcy in patients with hypertension combined with OSAHS were higher than those in patients with simple hypertension,and were positively correlated with the severity.Femoral intima media thickness and hypersensitive CRP and Hcy are valuable for detection of patients with hypertension complicated with OSAHS.