Influence Factors Of Early Hormone Changes After Transsphenoidal Resection Of Nonfunctional Pituitary Adenoma

Objective: To investigate the factors influencing the early recovery of hormone levels after endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas(NFPA).Method: The clinical data of 63 patients with nonfunctional pituitary adenomas undergoing neuroendoscopic surgery in our hospital were analyzed retrospectively,and the related factors that may affect the early recovery of hormone levels after surgery were analyzed.Results: According to the results of preoperative and postoperative hormone examination of patients,relevant comparative indicators were set,and it can be seen that 31 patients had improved or normal hormone levels after surgery,and 32 patients had abnormal or no improvement.Single hormone analysis showed that(T3/T4/TSH)had the worst postoperative improvement,and prolactin(PRL)had the best recovery.Univariate analysis showed that the volume,stage,invasion of tumor and the degree of preoperative hormone abnormality were related to the early postoperative hormone improvement(P<0.05).The binomial logistic multivariate analysis showed that the abnormal degree of preoperative hormone level of patients was an independent risk factor affecting the recovery of early postoperative hormone level.The higher the abnormal degree of preoperative hormone,the worse the recovery of early postoperative hormone(OR=4.96,95%CI:1.03-23.83,P=0.045).Conclusion: Patients with nonfunctional pituitary adenomas can be removed by surgery to relieve clinical symptoms,but the actual anterior pituitary function and related influencing factors of patients after surgery are not known.In the study of the influencing factors of early postoperative hormone changes,it was proved that the tumor size,volume,invasion and preoperative hormone abnormalities might be related to the early postoperative hormone recovery.